Evidence map›Paper›PMID 40766393›Full record

ArticlebioRxiv : the preprint server for biology2025

Gasdermin E is Dispensable for H1N1 Influenza Virus Pathogenesis in Mice.

Samuel Speaks, Jonathan Papa, Matthew McFadden, Jack E Roettger, Benjamin D Liu, Shreenath Mohan, Brendan M Reznik, Steve Leumi, Jana M Cable, Adriana Forero and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Samuel SpeaksDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0003-7610-1502
Jonathan PapaDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Matthew McFaddenDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jack E RoettgerDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Benjamin D LiuDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Shreenath MohanDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Brendan M ReznikDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Steve LeumiDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Jana M CableDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Adriana ForeroDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-2698-658X
Jacob S YountDepartment of Microbial Infection and Immunity, Wexner College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

Funding

Mechanisms of innate resistance to virus infectionsR01AI130110 · NIAID · OHIO STATE UNIVERSITY · PI Jacob Yount · 2017 to 2026
$4.3M
Protein therapy to treat virus induced cardiopulmonary injuryR01HL157215 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAI, CHUANXI, MA, JIANJIE · 2022 to 2025
$2.7M
NHLBI NIH HHS R01 HL157215NIAID NIH HHS R01 AI130110
6 · The paper itself

Abstract

Targeting cell death pathways, including pyroptosis and necroptosis, has been shown to mitigate influenza virus infection severity. Here, we examined whether pyroptosis specifically driven by the pore-forming protein gasdermin E (GSDME) is involved in regulating influenza virus infection outcomes. We found that

Identifiers

PMID40766393
PMCPMC12324273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.