Evidence map›Paper›PMID 40766381›Full record

ArticlebioRxiv : the preprint server for biology2025

Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity.

Alexandra C Belfi, Sage G Aviles, Rachel Forman-Rubinsky, Hasreet K Gill, Jennifer D Cohen, Aleksandra Nawrocka, Axelle Bourez, Pierre van Antwerpen, Patrick Laurent, Meera V Sundaram

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alexandra C BelfiDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia PA USA.
Sage G AvilesDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia PA USA.
Rachel Forman-RubinskyDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia PA USA.ORCID 0000-0002-1853-9456
Hasreet K GillDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia PA USA.ORCID 0000-0002-0718-5920
Jennifer D CohenDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia PA USA.ORCID 0000-0001-7810-7666
Aleksandra NawrockaLaboratory of Neurophysiology, ULB Institute for Neuroscience, Universite' Libre de Bruxelles, Bruxelles, Belgium.ORCID 0009-0008-1488-7622
Axelle BourezRD3-Pharmacognosy, Bioanalysis and Drug Discovery and Analytical Platform of the Faculty of Pharmacy, Universite libre de Bruxelles, Bruxelles, Belgium.ORCID 0000-0002-6130-381X
Pierre van AntwerpenRD3-Pharmacognosy, Bioanalysis and Drug Discovery and Analytical Platform of the Faculty of Pharmacy, Universite libre de Bruxelles, Bruxelles, Belgium.ORCID 0000-0002-4934-8863
Patrick LaurentLaboratory of Neurophysiology, ULB Institute for Neuroscience, Universite' Libre de Bruxelles, Bruxelles, Belgium.ORCID 0000-0001-5360-5597
Meera V SundaramDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia PA USA.ORCID 0000-0002-2940-8750

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Building and shaping the apical extracellular matrixR35GM136315 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Meera Sundaram · 2020 to 2026
$4.7M
Lipocalin-dependent glycocalyx organization and tube protectionR01GM125959 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SUNDARAM, MEERA · 2018 to 2019
$634k
NIGMS NIH HHS R01 GM125959NIGMS NIH HHS R35 GM136315NIH HHS P40 OD010440
6 · The paper itself

Abstract

All exposed epithelial surfaces, including the walls of internal tubes, are lined by a lipid and glycoprotein-rich apical extracellular matrix (aECM) that helps shape and protect the apical domain. Secreted lipocalins are lipid transporters frequently found within apical compartments. We show that loss of the

Identifiers

PMID40766381
PMCPMC12324240

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.