Evidence map›Paper›PMID 40766379›Full record

ArticlebioRxiv : the preprint server for biology2025

Microglia-to-neuron signaling increases lipid droplet metabolism, enhancing neuronal network activity.

Ana P Verduzco Espinoza, Na Na, Loraine Campanati, Priscilla Ngo, Kristin K Baldwin, Hollis T Cline

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ana P Verduzco EspinozaDepartment of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Na NaDepartment of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Loraine CampanatiDepartment of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Priscilla NgoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, CA, USA.
Kristin K BaldwinDepartment of Genetics and Development, Columbia Stem Cell Initiative, Columbia University Medical Center, New York, NY, USA.
Hollis T ClineDepartment of Neuroscience, The Scripps Research Institute, La Jolla, San Diego, CA, USA.ORCID 0000-0002-4887-9603

Funding

Contributions of cell type and exosome signaling to prodromal synaptic and circuit changes in Alzheimer's Disease modelsRF1AG079517 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI BALDWIN, KRISTIN KAY, CLINE, HOLLIS T. · 2022 to 2022
$2.6M
NIA NIH HHS RF1 AG079517
6 · The paper itself

Abstract

Microglia regulate neuronal circuit plasticity. Disrupting their homeostatic function has detrimental effects on neuronal circuit health. Neuroinflammation contributes to the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), with several microglial activation genes linked to increased risk for these conditions. Inflammatory microglia alter neuronal excitability, inducing metabolic strain. Interestingly, expression of

Indexed as

APOE4DDHD2exosomeshyperexcitabilityInflammatory microglianetwork activityneuronal lipid droplets

Identifiers

PMID40766379
PMCPMC12324536

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.