Evidence map›Paper›PMID 40766374›Full record

ArticlebioRxiv : the preprint server for biology2025

Striatal pathways oppositely shift cortical activity along the decision axis.

Jounhong Ryan Cho, Scott S Bolkan, Lindsey S Brown, Maja Skuza, Yousuf El-Jayyousi, Benjamin Midler, Robert N Fetcho, Christopher A Zimmerman, Alejandro Pan-Vazquez, Manuel Schottdorf and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jounhong Ryan ChoPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Scott S BolkanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Lindsey S BrownPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Maja SkuzaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Yousuf El-JayyousiPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Benjamin MidlerPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Robert N FetchoPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Christopher A ZimmermanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Alejandro Pan-VazquezPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Manuel SchottdorfPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Adrian G BondyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Misael A SanchezPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Juan F Lopez LunaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Alvaro LunaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Tim EilersPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Abigail S KalmbachPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Yang LuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Laura A LynchPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Ilana B WittenPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.

Funding

State-dependent Decision-making in Brainwide Neural CircuitsU19NS123716 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PANINSKI, LIAM M · 2021 to 2025
$18.2M
Subcortical Neural Coding and DynamicsU19NS104648 · NINDS · PRINCETON UNIVERSITY · PI BRODY, CARLOS D · 2017 to 2021
$15.3M
Project 4: Neural mechanisms underlying latent-cause inferenceP50MH136296 · NIMH · PRINCETON UNIVERSITY · PI DAVID HAROLD ZALD · 2024 to 2026
$12.9M
Individual differences through self-reinforcement of suboptimal strategiesDP1MH136573 · NIMH · PRINCETON UNIVERSITY · PI Ilana Witten · 2023 to 2026
$5.7M
Striatal substrates regulating sensory-guided and memory-guided behaviorsF32MH118792 · NIMH · PRINCETON UNIVERSITY · PI BOLKAN, SCOTT STEVEN · 2019 to 2021
$200k
Models for accumulation of evidence through sequences in a navigation-based, decision-making taskF32MH132179 · NIMH · PRINCETON UNIVERSITY · PI BROWN, LINDSEY SHOEMAKER · 2023 to 2024
$96k
NIMH NIH HHS DP1 MH136573NIMH NIH HHS F32 MH118792NIMH NIH HHS F32 MH132179NIMH NIH HHS P50 MH136296NINDS NIH HHS U19 NS104648NINDS NIH HHS U19 NS123716
6 · The paper itself

Abstract

The cortex and basal ganglia are organized into multiple parallel loops that serve motor, limbic, and cognitive functions. The classic model of cortico-basal ganglia interactions posits that within each loop, the direct pathway of the basal ganglia activates the cortex and the indirect pathway inhibits it

Identifiers

PMID40766374
PMCPMC12324368

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.