ArticlebioRxiv : the preprint server for biology2025
Inhibition of coronaviral exonuclease activity by TRIM-mediated SUMOylation.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Rewriting the viral script: post-translational modifications orchestrating SARS-CoV-2 pathogenesis and immune evasion.Frontiers in microbiology · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
Members of the TRIM E3 ligase family are effectors of the host innate or intrinsic defense against various viruses; however, how specific TRIM proteins antagonize coronavirus infection is still largely elusive. Through an RNAi screen targeting 71 human TRIM genes, we identified multiple TRIM proteins with antiviral or proviral activity against SARS-CoV-2. TRIM32 potently restricted SARS-CoV-2 replication in a RING E3 ligase-dependent but interferon-independent manner. Mechanistically, TRIM32 binds to and SUMOylates the 3'-to-5' exoribonuclease (ExoN) of NSP14, which is essential for SARS-CoV-2 replication. TRIM32-mediated NSP14 SUMOylation at K9 and K200 inhibits RNA binding and NSP10 cofactor recruitment, respectively, ultimately suppressing ExoN activity. Our study further revealed that NSP14 SUMOylation by TRIM32 and its antiviral activity are broadly conserved for coronaviruses. These results identify the coronaviral NSP14 protein as a direct target of host restriction via SUMOylation, which may uncover novel ways to therapeutically inhibit coronavirus infections in humans.
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