ArticlebioRxiv : the preprint server for biology2025
Formate reduces ischemic injury in female hearts lacking alcohol dehydrogenase 5.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ischemic heart disease is a primary cause of death for men and women in the United States. Recent epidemiologic findings, however, suggest that pre-menopausal women have inherent protection from many cardiovascular pathologies compared to age-matched men, which is lost with menopause. We and others have documented similar protective signaling in animal models, with females exhibiting protection from ischemic injury that is lost with ovariectomy (OVX). Furthermore, in recent studies, we demonstrated that the loss of alcohol dehydrogenase 5 (ADH5) blocked sex-specific cardioprotection in females, but activation of aldehyde dehydrogenase 2 (ALDH2) provided a rescue. ADH5 and ALDH2 both metabolize formaldehyde to formate, potentially implicating formate in female-specific cardioprotection. Therefore, the objective of this study was to examine a role for formate during ischemic injury in female hearts using wild-type (WT) and ADH5
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