Evidence map›Paper›PMID 40766319›Full record

Observational studyFrontiers in immunology2025

Рrospective multicenter study of treatment efficacy, safety, and quality of life in a large cohort of patients with inborn errors of immunity receiving subcutaneous immunoglobulin by the rapid push method.

Asmik Avedova, Elena Deripapa, Yulia Rodina, Anna Mukhina, Elena Latysheva, Daria Yukhacheva, Vasily Burlakov, Nellie Kan, Daria Bogdanova, Anna Moiseeva and 39 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

49 authors.

Asmik AvedovaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Elena DeripapaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Yulia RodinaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Anna MukhinaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Elena LatyshevaImmunopathology Department, National Research Center Institute of Immunology Federal Medical and Biological Agency (FMBA), Moscow, Russia.
Daria YukhachevaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Vasily BurlakovImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Nellie KanImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Daria BogdanovaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Anna MoiseevaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Natalia KuzmenkoImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Zoya NesterenkoImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Ekaterina DeordievaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Anna OgnevaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Victoria BludovaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Anna RoppeltMoscow Center of Allergy and Immunology, Clinical City Hospital 52 Ministry of Healthcare of Moscow, Moscow, Russia.
Daria FominaMoscow Center of Allergy and Immunology, Clinical City Hospital 52 Ministry of Healthcare of Moscow, Moscow, Russia.
Natalia ZinovievaImmunology Department, Children's City Clinical Hospital №9, Moscow, Russia.
Yulia SevostyanovaImmunology Department, Children's City Clinical Hospital №9, Moscow, Russia.
Linara KalmetevaImmunology Department, Republican Children's Clinical Hospital of the Ministry of Health of the Republic Bashkortostan, Ufa, Russia.
Dilara ProlyginaImmunology Department, Republican Children's Clinical Hospital of the Ministry of Health of the Republic Bashkortostan, Ufa, Russia.
Lyudmila BarychevaImmunology Department, Stavropol State Medical University of the Ministry of Health of Russia, Stavropol, Russia.
Olga SeleznevaImmunology Department, Regional Children's Clinical Hospital, Rostov-on-Don, Russia.
Natalya ShakhovaImmunology Department, Altai State Medical University of the Ministry of Health of Russia, Barnaul, Russia.
Olga LabaImmunology Department, Regional Children's Clinical Hospital, Yaroslavl, Russia.
Elena VlasovaImmunology Department, Regional Children's Clinical Hospital, Yekaterinburg, Russia.
Alla GorenkovaImmunology Department, Arkhangelsk Regional Children's Clinical Hospital named after P.G. Vyzhletsova, Arkhangelsk, Russia.
Elena TimofeevaImmunology Department, Nizhny Novgorod Regional Children's Clinical Hospital, Nizhny Novgorod, Russia.
Olga TrusovaImmunology Department, First St. Petersburg State Medical University named after acad. I.P. Pavlova, Saint Petersburg, Russia.
Marina GusevaImmunology Department, First St. Petersburg State Medical University named after acad. I.P. Pavlova, Saint Petersburg, Russia.
Natalya YudinaImmunology Department, Voronezh Regional Children's Clinical Hospital, Voronezh, Russia.
Evgeniya GrevtsevaImmunology Department, Voronezh Regional Children's Clinical Hospital, Voronezh, Russia.
Asya IbishevaImmunology Department, Republican Children's Clinical Hospital named after E.P. Glinka, Chechen Republic, Russia.
Zema BambaevaImmunology Department, Regional Children's Clinical Hospital, Republic of Buryatia, Russia.
Dina MashkovskayaImmunology Department, Republican Children's Clinical Hospital, Republic of Crimea, Russia.
Svetlana IsakovaImmunology Department, Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
Almazia ShakirovaImmunology Department, Children's Republican Clinical Hospital, Kazan, Russia.
Ekaterina SelinaImmunology Department, Children's Republican Clinical Hospital, Kazan, Russia.
Tatyana ShilovaImmunology Department, Chelyabinsk Regional Children's Clinical Hospital, Chelyabinsk, Russia.
Elena ZubovaImmunology Department, Children's Regional Hospital, Perm, Russia.
Iman KhabaevaImmunology Department, Regional Children's Clinical Hospital named after N.N. Silishchevoy, Astrakhan, Russia.
Ekaterina KitovaImmunology Department, Republican Children's Clinical Hospital, Republic of Crimea, Russia.
Anastasia MandzhievaImmunology Department, Regional Children's Clinical Hospital No. 1, Tyumen, Russia.
Svetlana StarikovaImmunology Department, City Children's Clinical Hospital №2 named after V.P. Bisyarina, Omsk, Russia.
Tatyana PavlovaImmunology Department, Irkutsk State Regional Children's Clinical Hospital, Irkutsk, Russia.
Elvira TyulyakovaImmunology Department, Children's City Clinical Hospital, Kaluga, Russia.
Pavel LevinImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Nikolay GrachevImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.
Anna ShcherbinaImmunology Department, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Subcutaneous immunoglobulin (SCIG) preparations are widely used in patients with inborn errors of immunity (IEI), with proven efficacy and good tolerance. We assessed treatment efficacy, safety, and quality of life in a large cohort of IEI patients who switched from intravenous immunoglobulin (IVIG) to SCIG. Our observational study included 200 patients aged 1-65 years with IEI. SCIG Cutaquig (16.5%) was administered every 7-10 days for at least 12 months via the rapid push method. We assessed the rate of infection, immunoglobulin G (IgG) concentration, adverse events, and quality of life. A total of 8,787 SCIG doses were administered during the study. The rate of infections (per person/month) during SCIG treatment was 0.05, which was significantly lower compared to 0.19 during the IVIG period (p<0.001). The median trough IgG was 6.9 g/L on IVIG, compared to 9.0 g/L during the first six months, and 9.2 g/L during the next six months on SCIG. Systemic reactions occurred in 12.4% of the IVIG infusions and 1.9% of the SCIG infusions. The total scores on quality of life summary assessments of physical and mental health were higher on SCIG therapy compared with IVIG (p<0.001). At the end of the study, 85.6% of the patients chose to remain on SCIG. Our data suggest that SCIG infusion via the rapid push method is effective, well tolerated, and feasible in large groups of IEI patients, including those in large countries such as Russia.

Indexed as

ImmunoglobulinsQuality of LifeAdolescentAdultAgedChildChild, PreschoolFemaleHumansImmunoglobulin GImmunoglobulins, IntravenousInfantInfusions, SubcutaneousInjections, SubcutaneousMaleMiddle AgedImmunoglobulin GImmunoglobulinsImmunoglobulins, Intravenousefficacyinborn errors of immunityintravenous immunoglobulinquality of liferapid pushsafetysubcutaneous immunoglobulintolerability

Identifiers

PMID40766319
PMCPMC12321879

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