ArticleFrontiers in immunology2025
GSDMD-NETs in patients with sepsis-induced coagulopathy and their interaction with glycocalyx damage.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A biomimetic microphysiological system predicts the impact of sepsis therapeutics on neutrophil-endothelial dynamics.Lab on a chip · 2026Article
- Research progress on neutrophil extracellular traps in sepsis‑induced coagulopathy (Review).Molecular medicine reports · 2026Review
- Delayed disulfiram targeting GSDMD-NETs axis rescues sepsis by limiting bacterial spread and lung injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Non-apoptotic Regulated Cell Death Mechanisms in Sepsis and their Therapeutic Potential.Inflammation · 2026Review
- Targeting neutrophil extracellular traps in bacterial infections: mechanistic insights and translational perspectives.Frontiers in immunology · 2026Review
- Endothelial Surface Glycocalyx in Vascular Functions and Diseases.Advances in experimental medicine and biology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Neutrophil extracellular traps (NETs) play a critical role in inflammation and coagulation imbalance. Recent studies have demonstrated that activation of gasdermin D (GSDMD) protein and its pore-forming activity are essential drivers of NET generation. This study investigated the association between GSDMD-NETs axis activation and sepsis-induced coagulopathy (SIC), as well as the potential association with glycocalyx damage. Materials and Methods: A prospective cohort of 70 sepsis patients (35 with SIC, 35 non-SIC) admitted to a respiratory intensive care unit was analyzed. This study was registered at the Chinese Clinical Trial Registry (ChiCTR) with the registration number ChiCTR2500100284. The trial can be accessed at https://www.chictr.org.cn/bin/project/edit?pid=266738. Plasma levels of GSDMD-NETs biomarkers (N-GSDMD, MPO-DNA) and glycocalyx injury markers (syndecan-1, MMP-9) were measured via ELISA. Clinical outcomes, thrombotic/hemorrhagic events, and biomarker correlations were evaluated using logistic regression, ROC analysis, and Pearson's correlation. Results: Compared to non-SIC patients, the SIC group exhibited higher rates of viral infections (31.4% Conclusion: The activation of the GSDMD-NETs axis is strongly associated with the development of SIC, glycocalyx injury, and adverse clinical outcomes in sepsis, potentially contributing to these pathological processes. Plasma N-GSDMD and MPO-DNA serve as predictive biomarkers for SIC severity and mortality, highlighting their potential role in targeted therapeutic strategies.
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