Evidence map›Paper›PMID 40766251›Full record

ArticleResearch square2025

The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.

John Maris, Isabel Soria-Bretones, Matias Casás-Selves, Minu Samanta, David Groff, Jayne Murray, Jamie Fletcher, Alvin Farrel, Steven Pastor, Khushbu Patel and 27 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors.

John MarisUniversity of Pennsylvania and Children's Hospital of Philadelphia.ORCID 0000-0002-8088-7929
Isabel Soria-BretonesRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Matias Casás-SelvesRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Minu SamantaChildren's Hosp of Philadelphia.
David GroffChildren's Hosp of Philadelphia.ORCID 0000-0001-6897-2656
Jayne MurrayChildren's Cancer Institute.
Jamie FletcherChildren's Cancer Institute Australia.ORCID 0000-0003-2949-9469
Alvin FarrelChildren's Hospital of Philadelphia.ORCID 0000-0003-1087-9840
Steven PastorChildren's Hospital of Philadelphia.
Khushbu PatelChildren's Hosptial of Philadelphia.
Elliot Goodfellow GoodfellowRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Li LiRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Cathy CaronRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Ariya ShiwramRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Hyeyeon KimRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Danielle HenryRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Nancy LaterreurRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Julian BowlanRepare Therapeutics, Inc., Cambridge, MA, USA.
Kateryna KrytskaChildren's Hosptial of Philadelphia.
Steven NeuhauserThe Jackson Laboratory.
Timothy StearnsThe Jackson Laboratory, Bar Harbor, ME, USA.
Jeffrey SchubertChildren's Hospital of Philadelphia.
Jinhua WuChildren's Hospital of Philadelphia.
Lea SurreyChildren's Hospital of Philadelphia.ORCID 0000-0002-6944-2232
Alejandro Álvarez-QuilónRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Frédéric ValléeRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Parham NejadRepare Therapeutics, Inc., Cambridge, MA, USA.
Joseph SchonhoftRepare Therapeutics, Inc., Cambridge, MA, USA.
Joanna LiRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Artur VelosoRepare Therapeutics.
Jordan YoungRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Marc HyerRepare Therapeutics, Inc., Cambridge, MA, USA.
Stephen MorrisRepare Therapeutics, Inc., St. Laurent, QC, Canada.
Yael P MosséChildren's Hospital of Philadelphia.ORCID 0000-0002-3463-0399
Gary MarshallRepare Therapeutics.
Michelle HaberExperimental Therapeutics Program.ORCID 0000-0003-2036-8817
Michal ZimmermannRepare Therapeutics.ORCID 0000-0002-9955-1675

Funding

Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomesR35CA220500 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI JOHN M MARIS · 2017 to 2026
$8.7M
NCI NIH HHS R35 CA220500
6 · The paper itself

Abstract

It was recently shown that inhibition of polo-like kinase 4 (PLK4) induces

Identifiers

PMID40766251
PMCPMC12324582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.