Evidence map›Paper›PMID 40766249›Full record

ArticleResearch square2025

Drug-induced metabolic remodeling of immune cell repertoire generates an effective broad-range antimicrobial effect.

Bhupesh Kumar Prusty, Claudia Hollmann, Eun Chan Park, Zheng Liu, Faye Nourollahi, Georgy Nikolayshvili, Jonathan Dietz, Emils Bašēns, Mehul Vora, Trushnal Waghmare and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bhupesh Kumar PrustyRiga Stradins University.ORCID 0000-0001-7051-4670
Claudia HollmannJulius-Maximilians University of Würzburg.
Eun Chan ParkThe Waksman Institute, Rutgers The State University of New Jersey.
Zheng LiuJulius-Maximilians University of Würzburg.
Faye NourollahiThe Waksman Institute, Rutgers The State University of New Jersey.
Georgy NikolayshviliRiga Stradins University.
Jonathan DietzThe Waksman Institute, Rutgers The State University of New Jersey.
Emils BašēnsRiga Stradins University.
Mehul VoraModOmics Ltd.
Trushnal WaghmareRiga Stradins University.
Tongbin LiAccuraSciences.
Fabian ImdahlHelmholtz Institute for RNA-based Infection Research.
Christopher RongoThe Waksman Institute, Rutgers The State University of New Jersey.

Funding

Genetics Analysis of Neuronal Hypoxic Stress ResistanceR01GM101972 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI RONGO, CHRISTOPHER G · 2012 to 2024
$4.1M
NIGMS NIH HHS R01 GM101972
6 · The paper itself

Abstract

Multiple mechanisms of immunity must be coordinated to defend against a comprehensive range of pathogens; however, the mechanisms by which broad-spectrum antipathogens act remain largely elusive. Here, we employed systems biology approaches to understand the organization of human immune cells at the single-cell level, as well as their reorganization in response to K21, a silane derivative effective against viral, bacterial, and fungal infections. K21 induced pro-inflammatory pathways in M1 and M2c macrophages without altering cytokine secretion, decreased a specific subtype of M1 macrophages and CXCL4-induced M2-like macrophages, and improved mitochondrial health by enhancing mitochondrial recycling via mitophagy. Similar treatment of the

Identifiers

PMID40766249
PMCPMC12324592

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.