Evidence map›Paper›PMID 40766243›Full record

ArticleResearch square2025

Exploiting Large Language Models for Diagnosing Autism Associated Language Disorders and Identifying Distinct Features.

Chuanbo Hu, Wenqi Li, Mindi Ruan, Xiangxu Yu, Shalaka Deshpande, Lynn K Paul, Shuo Wang, Xin Li

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Chuanbo HuDepartment of Computer Science, University at Albany, Albany, 12222, NY, USA.
Wenqi LiDepartment of Computer Science, University at Albany, Albany, 12222, NY, USA.
Mindi RuanLane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, 26506, WV, USA.
Xiangxu YuDepartment of Radiology, Washington University in St. Louis, St. Louis, 63110, MO, USA.
Shalaka DeshpandeCamas High School, Camas, 98607, WA, USA.
Lynn K PaulHumanities and Social Sciences, California Institute of Technology, Pasadena, 91125, CA, USA.
Shuo WangDepartment of Radiology, Washington University in St. Louis, St. Louis, 63110, MO, USA.
Xin LiDepartment of Computer Science, University at Albany, Albany, 12222, NY, USA.

Funding

Model-Based Investigation of Aberrant Neural Face Representation in AutismR01MH129426 · NIMH · WASHINGTON UNIVERSITY · PI Shuo Wang · 2022 to 2026
$1.9M
NIMH NIH HHS R01 MH129426
6 · The paper itself

Abstract

Diagnosing language disorders associated with autism is a complex challenge, often hampered by the subjective nature and variability of traditional assessment methods. In this study, we explored Large Language Models (LLMs) to overcome the speed and precision obstacles by enhancing sensitivity and profiling linguistic features for autism diagnosis. This research utilizes natural language understanding capabilities of LLMs to simplify and improve the diagnostic process, focusing on identifying autism-related language patterns. We showed that the proposed method demonstrated improvements over the baseline models, with over a 10% increase in both sensitivity and positive predictive value in a zero-shot learning configuration. Combining accuracy and applicability, the framework could serve as a valuable supplementary tool within the diagnostic process for ASD-related language patterns. We identified ten key features of autism-associated language disorders across scenarios. Features such as echolalia, pronoun reversal, and atypical language usage play a critical role in diagnosing ASD and informing tailored treatment plans.

Indexed as

Autism spectrum disorder (ASD)Generative Pre-trained Transformer (GPT)Identified linguistic featuresLanguage deficitsLarge language models (LLMs)

Identifiers

PMID40766243
PMCPMC12324599

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.