ArticleResearch square2025
The association between baseline and long-term status of metabolic score for insulin resistance index and the incidence of cardiometabolic multimorbidity.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cardiometabolic multimorbidity (CMM) is concurrently associated with a reduction in life expectancy and an increased propensity for all-cause mortality. Our objective was to evaluate the correlations between the baseline and longitudinal metabolic score for insulin resistance index (METS-IR) and the incidence of cardiometabolic multimorbidity (CMM) within a middle-aged and older Chinese population cohort.. Methods and Results: A total of 8,050 participants were enrolled and included in the analytical dataset for this study. Long-term status of METS-IR were defined as updated mean METS-IR and high METS-IR exposure duration. Updated mean METS-IR was defined as the mean of the two METS-IR measurements. High METS-IR exposure duration was defined as the times of visits with a high METS-IR among the 2 visits, quantified as 0 year, 2 years and 4 years according to the optimal cut points from the receiver operating characteristic curves of the two METS-IR measurements, respectively. The outcome was defined as the occurrence of CMM, characterized by the presence of two or more cardiometabolic disorders as self-reported by participants, encompassing conditions such as diabetes, stroke, and cardiac events. During 6-year visit, 540 participants experienced CMM. Substantially elevated incidences of CMM were observed in participants belonging to the highest tertiles of both baseline and updated mean METS-IR. After multivariable adjustment, the odds ratios (ORs) with 95% confidence intervals (CIs) for CMM were 2.94 (CI: 2.04-4.22) for those in the highest baseline METS-IR tertile and 3.26 (CI: 1.90-5.59) for those in the highest updated mean METS-IR tertile, relative to participants in the lowest tertiles. Multivariable-adjusted spline regression models showed a linear association of baseline METS-IR ( Conclusion: This study proved elevated baseline METS-IR, updated mean METS-IR, especially high METS-IR exposure duration was associated with CMM incidence among middle-aged and older Chinese.
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