Strain-based biomarkers at the skin surface detect changes in soft tissue mobility linked to myofascial pain following soft tissue manipulation intervention.

Soft tissue manipulation is a widely used massage-based intervention in treating myofascial pain, yet its efficacy in increasing tissue mobility is evaluated primarily through subjective observations. To establish objective measures of tissue mobility, this study captures patterns of skin surface deformation during hands-on clinician assessment using digital image correlation. Nineteen participants underwent an established soft tissue manipulation (STM) intervention protocol targeting the cervicothoracic region. Tissue mobility was assessed bilaterally (left v. right) and directionally (superior v. inferior) before and after the STM intervention using eleven strain-based biomarkers. Post-intervention, those biomarkers associated with tissue deformation and glide exhibited systematic changes, indicating increased mobility. Notably, 88% of participants demonstrated improved tissue mobility, especially on the more restricted body side. Among participants reporting more pain on one side of the body, 90% exhibited greater post-intervention improvement on the more painful side. Moreover, distinctions in the strain-based biomarkers well aligned with self-reported pain, supporting their potential for objective assessment of myofascial dysfunction. This study highlights the feasibility of optical skin surface tracking as a tool for evaluating the efficacy of STM intervention, offering a quantitative, low-cost, and realistic clinical approach.