ArticleLaryngoscope investigative otolaryngology2025
Congestion and Sinonasal Illness in Outer Space: A Study on the International Space Station.
Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Congestion and Sinonasal Illness in Outer Space: A Study on the International Space Station.Laryngoscope investigative otolaryngology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study aims to characterize quantitative data pertaining to sinonasal symptoms and their related medication use aboard the International Space Station (ISS). A secondary focus involves correlating these findings with mission parameters such as extravehicular activity (EVA) participation and mission duration. Methods: This retrospective cohort study was conducted utilizing data requested from the National Aeronautics and Space Administration (NASA) Lifetime Surveillance of Astronaut Health (LSAH) program. Results: Of 71 de-identified ISS astronauts beginning with Expedition 1 in the year 2000 through 62 in 2019, there were 754 logged medical events; 60 astronauts reported any type of sinonasal medical event (85%), the most common being general nasal congestion in 53 astronauts (75%). Symptoms were attributed to microgravity-induced fluid shifts in 34 astronauts (57%) while 17 (28%) attributed symptoms to ear clearing and barotrauma. Pseudoephedrine was the most used medication, with 95 recorded uses, followed by oxymetazoline spray at 51. Among the 60 astronauts with sinonasal medical events, the 24 with references to extravehicular activity (EVA) participation in their records had on average, 9.19 more records than those without (95% CI: 2.29-17.06). Conclusion: Sinonasal symptoms are a prevalent medical concern among astronauts aboard the ISS. The findings suggest that early spaceflight-associated fluid shifts contribute significantly to these symptoms, often requiring medication use. A correlation between EVA participation and a higher number of medical events highlights an occupational risk factor. Level of Evidence: 3.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.