Evidence map›Paper›PMID 40766078›Full record

ArticleFrontiers in microbiology2025

A stable systemic infection of methicillin-resistant

Adrienne J Gamblin, Max C Peterson, Samantha S Simon, Tatyana Orekov, Erica Penn, Gabriella Shumyatsky, Grishma Patel, Amanda Womer, Helal Kabir, Darnell Bushby and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Adrienne J GamblinBIOQUAL, Inc., Rockville, MD, United States.
Max C PetersonBIOQUAL, Inc., Rockville, MD, United States.
Samantha S SimonBIOQUAL, Inc., Rockville, MD, United States.
Tatyana OrekovBIOQUAL, Inc., Rockville, MD, United States.
Erica PennBIOQUAL, Inc., Rockville, MD, United States.
Gabriella ShumyatskyBIOQUAL, Inc., Rockville, MD, United States.
Grishma PatelBIOQUAL, Inc., Rockville, MD, United States.
Amanda WomerBIOQUAL, Inc., Rockville, MD, United States.
Helal KabirBIOQUAL, Inc., Rockville, MD, United States.
Darnell BushbyBIOQUAL, Inc., Rockville, MD, United States.
Jeanne MuenchBIOQUAL, Inc., Rockville, MD, United States.
Karen FelicianoBIOQUAL, Inc., Rockville, MD, United States.
Fabian PazBIOQUAL, Inc., Rockville, MD, United States.
Brad FinneyfrockBIOQUAL, Inc., Rockville, MD, United States.
Anthony CookBIOQUAL, Inc., Rockville, MD, United States.
Swagata KarBIOQUAL, Inc., Rockville, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: Following a pilot study to determine the optimal dose and route to establish systemic MRSA infection, we challenged six cynomolgus macaques with 10 Results: An IV dose of 10 Discussion: In this study, we establish a non-human primate model of systemic MRSA infection that allows for the characterization of MRSA pathogenesis and evaluation of therapeutics over a period of days rather than hours. This model successfully recapitulates key aspects of human MRSA bloodstream infections, providing a valuable platform for evaluating therapeutic interventions and understanding disease mechanisms.

Indexed as

bacterial infection modelcynomolgus macaqueMRSAnonhuman primateS. aureus bacteremiasepsisStaphylococcus aureus

Identifiers

PMID40766078
PMCPMC12322839

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.