Factors contributing to the delayed diagnosis of endometriosis-a systematic review and meta-analysis.

Background: Endometriosis is a prevalent gynecological disorder that is estimated to affect approximately 10% of women of childbearing age globally. However, the condition remains significantly under-or misrecognized, and the mean time to diagnosis is several years. These delays result in increased symptom severity, diminished quality of life, and adverse long-term reproductive outcomes. Therefore, the aim of this systematic review and meta-analysis was to estimate the sources of diagnostic delay and their effects. Methods: The articles were retrieved from PubMed, Cochrane, and Google Scholar databases after performing a rigorous literature search. The initial search yielded 2,348 records, and 10 articles were included in the final analysis. Causes of diagnostic delay were classified under patient, physician, and systems attributes. Random-effects analysis was used to estimate the overall SMDs with 95% confidence intervals (CIs). For the primary Results: Patient-related factors demonstrated a significant pooled effect size (SMD: 1.94, 95% CI: 1.62-2.27, Conclusion: The results indicate that diagnostic delays in endometriosis are a function of multiple factors, with key contributions from patient and provider-related barriers. To close these gaps, targeted interventions such as public education to combat symptom normalization and stigmatization, more comprehensive provider training, and streamlined diagnostic pathways are needed. Future research can evaluate system-level changes and non-invasive diagnostic tools to reduce systemic delays further.