Evidence map›Paper›PMID 40766069›Full record

ArticleFrontiers in medicine2025

Case Report: A novel KRT74 variant in an eight-year-old boy with alopecia totalis successfully treated with baricitinib.

Yidong Tan, Jinxiang Yang, Xuanyi Chen, Yihang Shen, Zhe Wu, Weinan Zhou, Zhirong Yao, Jingjun Zhao, Jianying Liang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yidong Tan *Department of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jinxiang Yang *Department of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuanyi Chen *Department of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yihang ShenDepartment of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhe WuDepartment of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weinan ZhouDepartment of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhirong YaoDepartment of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jingjun ZhaoDepartment of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jianying LiangDepartment of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alopecia areata is an autoimmune condition characterized by non-scarring hair loss, with genetic factors playing a significant role in disease susceptibility. We report the case of an 8-year-old boy with alopecia totalis harboring a heterozygous KRT74 variant. While his mother and brother share this variant, they do not exhibit alopecia. Immunofluorescence analysis revealed increased phosphorylation of the JAK1-STAT1 pathway and elevated T cell infiltration, predominantly CD4

Indexed as

alopecia totalisbaricitinibJAK1-STAT1 pathwayKRT74 variantleukonychia

Identifiers

PMID40766069
PMCPMC12321523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.