ArticleJournal of inflammation research2025
Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn's Disease: A Cross-Sectional Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Comparative metagenomic characterization of gut microbiota and antibiotic resistome in multi-facility SPF mice.BMC microbiology · 2026Article
- Microbiota and Gut Inflammatory Markers (Zonulin and Fecal Calprotectin) Exhibit Age-Dependent Variation in Patients with Ulcerative Colitis.Life (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate the potential benefits of physical activity (PA) on patient-reported outcomes (PROs) in individuals with Crohn's disease (CD) and to examine whether these benefits are associated with gut microbiota. Methods: This cross-sectional study included 251 patients with CD from two inflammatory bowel disease centers in China. Participants with CD provided information on their health background, PA, and PROs using the Global Physical Activity Questionnaire (GPAQ) and the Patient-reported Outcome Measurement Information System (PROMIS). Part of participants also provided a single fecal sample for analysis. Latent profile analysis (LPA) was conducted to categorize individuals with CD into classes based on PROs. Metagenomic sequencing was then performed, followed by bioinformatics assessment of taxonomy and diversity metrics. Results: LPA identified two PRO patterns: low and high symptoms. Univariate and multivariate analyses indicated that disease activity and sedentary behavior were risk factors for symptom severity, whereas recreational PA, rather than work-and travel-related PA, and income served as protective factors (all Conclusion: Promoting the incorporation of recreational PA as an indicator of healthy lifestyle management for CD may improve patients' subjective psychological and mental well-being, while also preserving intestinal microbial diversity. Recreational PA is associated with favorable patient-reported outcomes and increased diversity of gut microbiota in CD, supporting its inclusion in lifestyle management strategies.
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