Evidence map›Paper›PMID 40765816›Full record

ArticleInternational journal of biological sciences2025

Stabilization of OLFML1 via m

Yan Zhong, Jingfeng Liu, Wenwen Lin, Tian Peng, Lingfang Gao, Lan Shen, Ping Wang, Zhiyan Hu, Ting Long, Zuguo Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan ZhongDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Jingfeng LiuShenzhen Key Laboratory of Immunity and Inflammatory Diseases, Peking University Shenzhen Hospital, Shenzhen, China.
Wenwen LinDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Tian PengDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Lingfang GaoDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Lan ShenDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Ping WangDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Zhiyan HuDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Ting LongDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Zuguo LiDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.
Jingquan LiuDepartment of Pathology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) progression is closely associated with cancer stemness, which contributes to poor prognosis and therapeutic resistance. This study identifies OLFML1 as a key target accounting for CRC progression. High expression of OLFML1 promotes CRC cell proliferation and cancer stemness. As for mechanism study, we further revealed that IGF2BP3 as a critical up-stream regulator of OLFML1. Our study indicated that IGF2BP3 stabilizes OLFML1 mRNA through m

Indexed as

Colorectal NeoplasmsHedgehog ProteinsNeoplastic Stem CellsRNA-Binding ProteinsAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiceSignal TransductionHedgehog ProteinsIGF2BP3 protein, humanRNA-Binding Proteinscancer stemnesscolorectal cancerHedgehog signaling pathwayIGF2BP3m6A modificationOLFML1

Identifiers

PMID40765816
PMCPMC12320246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.