Assessment of Prior Infection With Histoplasmosis Using Skin Test and Serological Surveys: A Global Systematic Review.

Rachael A Brooks, Kelly Yan, Jennifer R Head

Abstract readReview

In one paragraph

Review in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Clinical Performance of a Mp1p Antibody Detection Immunoassay For Talaromycosis.medRxiv : the preprint server for health sciences · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rachael A BrooksDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0009-0000-8568-3434

Kelly YanDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.

Jennifer R HeadDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-1449-4171

Funding

Modelled estimation of population immunity for coccidioidomycosis and the role of immunologically naïve populations in the shifting epidemiology of coccidioidomycosis in CaliforniaK01AI173529 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jennifer Head · 2023 to 2026

$478k

NIAID NIH HHS K01 AI173529

6 · The paper itself

Abstract

Background: Evidence suggests geographic expansion in histoplasmosis, a fungal infection caused by Methods: To summarize what is known regarding the distribution of histoplasmosis globally, we conducted a systematic review of studies reporting prevalence of lifetime or recent exposure to Results: We included 224 studies, including 171 skin test surveys and 44 serological surveys, spanning 66 countries and all 6 World Health Organization regions. Prevalence of infection exceeded 10% in studies from the Americas, Southeast Asia, and Africa, with substantial variation across population subgroups. Most studies used nonrepresentative sampling. Conclusions: Histoplasmosis likely exists along a global gradient. Surveillance and research efforts must shift to address its broad distribution and ensure timely diagnosis and treatment, especially in areas not traditionally considered endemic.

Indexed as

endemicityHistoplasma capsulatumhistoplasmosisIgGIgMprior infectionserologyskin testsystematic review

Identifiers

PMID40765713

DOI10.1093/ofid/ofaf437

PMCPMC12321522

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.