ArticleFrontiers in neurology2025
Non-coding repeat analyses in patients with Parkinson's disease.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Comprehensive Characterization of Clinical Phenotypes and CTG Repeat-Associated Manifestations in Spinocerebellar Ataxia Type 8.Cerebellum (London, England) · 2026Article
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15 authors.
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Abstract
Introduction: The genetic etiology of Parkinson's disease (PD) is complex; approximately 10% of patients with PD have various gene mutations that lead to familial forms of the disease. Recent analyses of non-coding repeat regions revealed that many neurodegenerative diseases are associated with pathological expansions. We evaluated the genetic background of non-coding repeat expansions in Japanese patients with PD. Methods: We collected blood samples from 203 Japanese patients with PD and analyzed various non-coding repeat genes, including Results: Three patients with PD (1.5%) were found to have heterozygous repeat expansions in Discussion: Our findings revealed the importance of non-coding repeat expansions in Japanese patients with PD. This is the first study to show the positive result of non-coding repeat expansions in many patients with PD in Japan.
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