Evidence map›Paper›PMID 40765605›Full record

ReviewCureus2025

Proton Pump Inhibitor Use and Risk of Clostridioides difficile Infection: An Umbrella Review of 11 Meta-Analyses.

Srinivas Nalabothula, Shivali Chava, Neha Sai P Doddapaneni, Harsha Sai K Gottimukkala, Divya Durga

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Srinivas NalabothulaMedicine and Surgery, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Vijayawada, IND.
Shivali ChavaHealth Sciences, University of Texas at Austin, Austin, USA.
Neha Sai P DoddapaneniInternal Medicine, NRI Medical College, Chinakakani, IND.
Harsha Sai K GottimukkalaMedicine, UTHealth Houston School of Public Health, Houston, USA.
Divya DurgaMedicine, NRI Medical College, Chinakakani, IND.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proton pump inhibitors (PPIs) are widely used for acid-related conditions. However, multiple studies have reported a potential link between PPI use and an increased risk of

Indexed as

acid suppressionclostridioides difficile infectionmeta-analysisppi stewardshipproton-pump inhibitors (ppi)umbrella review

Identifiers

PMID40765605
PMCPMC12324808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.