ArticleCureus2025
Antibiotic Prophylaxis in Orthopaedic Surgery: A Review and Institutional Experience.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Modulation of Surgical Site Infection Risk in Spinal and Thoracic Surgeries Through Operative Parameters: A Narrative Review.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical site infections (SSIs) are a significant complication in orthopaedic surgery. Effective use of antimicrobial prophylaxis is critical in reducing their incidence without promoting resistance.
objectivesTo review current evidence on antibiotic prophylaxis in orthopaedic surgery and to analyse data from our institution on the effectiveness of current prophylaxis protocols.
methodsWe carried out a literature review and a retrospective analysis of 1,000 orthopaedic surgeries done over a two-year period. The timing and duration of antibiotic prophylaxis and its association with postoperative SSI rates were evaluated. The standard was compared with the current antibiotic prophylaxis guidelines from our trust policy.
resultsOur institutional data demonstrated no statistically significant difference in SSI rates between patients who received 24-hour versus those who received extended antibiotic prophylaxis. Recent literature consistently supports the timely administration of preoperative antibiotics and discourages prolonged use beyond 24 hours. This is in line with our trust policy.
conclusionPreoperative administration of a single dose of antibiotic or a maximum of two doses remains effective in preventing SSIs. Extending prophylaxis beyond 24 hours offers no additional benefit and may promote antimicrobial resistance.
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Registered trials
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