ArticleJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2025
Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series.
Article in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
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16 authors.
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Abstract
BACKGROUND AND
objectivesPemphigoid diseases are primarily mediated by IgG or IgA autoantibodies against the cutaneous basement membrane zone (BMZ). Although recent observations suggest the existence of exclusively IgM-mediated pemphigoid disease, a larger study is lacking. PATIENTS AND
methodsThis prospective multicenter study included ten patients with exclusive IgM deposition along the BMZ by direct immunofluorescence (IF). Circulating IgM was detected by indirect IF and immunoblotting with recombinant BP180.
resultsThe cohort, four females and six males with a median age of 77 years, presented predominantly with prurigo-like lesions without blisters and mucosal involvement. Sera from nine patients demonstrated linear IgM labeling the blister roof of human salt-split skin by indirect IF. Four patients yielded IgM reactivity against BP180, but none against BP230. In none of the controls (n = 100), anti-BMZ IgM was seen by direct IF. 1/30 and 3/60 controls with or without pruritic non-pemphigoid diseases revealed serum IgM reactivity against the BMZ, respectively.
conclusionsIgM pemphigoid is characterized by exclusive tissue-bound anti-BMZ IgM, serum anti-BMZ IgM reactivity with BP180 as main target antigen, a predominantly non-bullous clinical phenotype, absence of mucosal involvement, and a rather mild disease course. Our findings indicate that IgM pemphigoid may represent a distinct entity.
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