Evidence map›Paper›PMID 40765369›Full record

ArticleAnaesthesia2025

Trends in greenhouse gas emissions from volatile anaesthetics in 41 countries: 2013-2023.

Marta Caviglia, Andrealuna Ucciero, Andrea Conti, Aurora Di Filippo, Francesco Trotta, Luca Ragazzoni, Francesco Della Corte, Francesco Barone-Adesi

Abstract read
In one paragraph

Article in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marta CavigliaCentre for Research and Training in Disaster Medicine, Humanitarian Aid and Global Health, Università del Piemonte Orientale, Novara, Italy.ORCID 0000-0002-4164-4756
Andrealuna UccieroHospital Pharmacy AOU Maggiore della Carità, Novara, Italy.
Andrea ContiDepartment of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
Aurora Di FilippoItalian Medicines Agency, Rome, Italy.
Francesco TrottaItalian Medicines Agency, Rome, Italy.
Luca RagazzoniCentre for Research and Training in Disaster Medicine, Humanitarian Aid and Global Health, Università del Piemonte Orientale, Novara, Italy.
Francesco Della CorteCentre for Research and Training in Disaster Medicine, Humanitarian Aid and Global Health, Università del Piemonte Orientale, Novara, Italy.
Francesco Barone-AdesiCentre for Research and Training in Disaster Medicine, Humanitarian Aid and Global Health, Università del Piemonte Orientale, Novara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInhalational anaesthetics contribute to greenhouse gas emissions, leading to regulatory restrictions in some countries. This study analysed time trends of greenhouse gas emissions directly attributable to the use of volatile anaesthetic agents in 41 countries.

methodsSales data were obtained using data from IQVIA MIDAS® and national medicines agencies. We calculated the kilograms of carbon dioxide equivalents (based on global warming potential) per capita and percentage change in greenhouse gas emissions, from the emission of volatile anaesthetics from 2018 to 2023.

resultsData were obtained for 41 countries, representing approximately 35% of the global population. Greenhouse gas emissions associated with volatile anaesthetic agents decreased in the 27 European Union nations and other 'western' countries included in the study (Australia, Canada, New Zealand, UK and USA), achieving in some cases below 0.5 kg of carbon dioxide equivalents per inhabitant. In contrast, several Asian countries showed a substantial increase in emissions, with South Korea and Japan reporting the highest values globally (approximately 2.5 kg of carbon dioxide equivalents per inhabitant). A secondary analysis restricted to European countries showed a 17-fold difference in per-capita carbon-equivalent emissions between the highest and lowest emitters, suggesting that recommendations on the use of volatile anaesthetic agents are implemented inconsistently. DISCUSSION: Our study highlighted large differences in the management of greenhouse gas emissions attributable to volatile anaesthetic use. While results show a decreasing trend in western countries, albeit with substantial variation, rising trends observed in many Asian countries may constitute a source of concern. The experience of nations that have phased out the highest impacting volatile anaesthetic agents show that reducing emissions below 0.5 kg of carbon dioxide equivalents per inhabitant is attainable. This should serve as a model for other systems, prompting implementation of educational initiatives and specific policies.

Indexed as

Anesthetics, InhalationGreenhouse GasesCarbon DioxideGlobal WarmingHumansAnesthetics, InhalationCarbon DioxideGreenhouse Gasesanaesthesiaenvironmentgreenhouse gaseshalogenatesvolatile anaesthetics

Identifiers

PMID40765369
PMCPMC12614409

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.