Evidence map›Paper›PMID 40765259›Full record

ArticleJournal of inherited metabolic disease2025

Dietary Shift Leads to Venous Thrombosis-Induced Congestive Liver Failure in CBS-Deficient Mice.

Hyung-Ok Lee, Cathy Q Qai, Michael J Slifker, Warren D Kruger

Abstract read
In one paragraph

Article in Journal of inherited metabolic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hyung-Ok LeeCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Cathy Q QaiCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Michael J SlifkerCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Warren D KrugerCancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4990-3695

Funding

GENETIC MODULATION OF CBS TO LOWER PLASMA HOMOCYSTEINER01HL057299 · NHLBI · FOX CHASE CANCER CENTER · PI KRUGER, WARREN D · 2001 to 2009
$3.2M
HCU America FoundationNCI NIH HHSNHLBI NIH HHS R01 HL057299
6 · The paper itself

Abstract

Cystathionine beta-synthase (CBS) deficiency is an inborn error of metabolism that results in a large increase in plasma total homocysteine (tHcy) and a significant risk of venous thrombosis. Although a mouse model of CBS deficiency (Tg-I278T Cbs

Indexed as

Cystathionine beta-SynthaseDietHomocystinuriaLiver FailureVenous ThrombosisAnimalsDisease Models, AnimalLiverMaleMethionineMiceMice, Inbred C57BLMice, KnockoutPhenotypeCystathionine beta-SynthaseMethionine

Identifiers

PMID40765259
PMCPMC12969802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.