ArticleBiophysical journal2025
Orexinergic regulation of GABAergic input onto pyramidal neurons in the anterior cingulate cortex.
Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Orexin, a neuropeptide synthesized exclusively in the hypothalamus, projects its efferent fibers widely across nearly all brain regions and plays a role in the pathophysiology of psychiatric disorders by binding to and activating orexin receptor 1 (OX1R) and/or orexin receptor 2 (OX2R). The anterior cingulate cortex (ACC), particularly its pyramidal neurons, is known to play a critical role in fundamental cognitive and social processes. In this study, we investigated the effects of orexin-A on GABAergic transmission onto pyramidal neurons in the ACC of juvenile rats. Orexin-A was found to enhance both the frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs). This increase in mIPSC frequency depended on Ca
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