SynthesisCancer reports (Hoboken, N.J.)2025
Survival and Clinicopathological Significance of CD47 in Human Solid Tumors: An Updated Systematic Reviews and Meta-Analysis.
Synthesis in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Survival and Clinicopathological Significance of CD47 in Human Solid Tumors: An Updated Systematic Reviews and Meta-Analysis.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- Targeting the CD47-SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next-generation therapeutic strategies.Smart molecules : open access · 2026Review
- Analysis of Prognostic Significance of CD47 Expression in Newly Diagnosed Large B Cell Lymphoma.Life (Basel, Switzerland) · 2026Article
- B7-H3 (CD276) and CD47 Expression Are Associated with Immune Evasion and Survival Outcomes in Pediatric Medulloblastoma.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundHigh expression levels of cluster of differentiation 47 (CD47) have been recognized as poor survival in several different cancers. Nevertheless, the significance of CD47 in patients with solid tumors remains controversial.
aimsThe objective of this study is to elucidate whether elevated CD47 expression independently predicts a poor prognosis across solid tumors through pooled survival and clinicopathological analyses. METHODS AND
resultsThis meta-analysis was based on a search of PubMed, Embase, and Web of Science databases to obtain 20 eligible published studies (totaling 4019 patients) between January 2018 and January 2024. The combined hazard ratios (HRs) for overall survival (OS) were evaluated, and the HRs for relapse-free survival (RFS), progression-free survival (PFS), and disease-free survival (DFS), as well as odds ratios for clinicopathological data, were also respectively combined. The data obtained from these studies were extracted from these published studies and analyzed. This study suggested that CD47 overexpression was related to shorter OS times in human solid tumors, with a combined HR for OS (according to the univariate analysis) of HR = 1.63 (95% confidence intervals,[ 95% CIs]: 1.45-1.83; p < 0.00001), and a pooled HR for OS (according to the multivariate analysis) of HR = 2.02 (95% CI: 1.43-2.84; p < 0.0001). The subgroup analysis revealed that CD47 overexpression was related to inferior OS rates according to country, cancer type, sample size, analysis type, and the method via which the HR value was obtained (i.e., reported or extracted; p < 0.05); in addition, a high expression level of CD47 was also a predictor of poor DFS, PFS, and RFS rates (p < 0.00001). Certain factors, such as age (≥ 60 years old), lymph node metastasis, TNM staging, differentiation type, and tumor recurrence, resulted in an upregulation of CD47 (p < 0.05).
conclusionThis meta-analysis indicates that CD47 overexpression is significantly associated with poor clinical outcomes, advanced clinical stages, and poor differentiation in solid tumor patients, particularly, in cases involving tumors in the digestive and respiratory systems. These findings suggest that CD47 could serve as a valuable prognostic biomarker and therapeutic target.
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