ArticleAntimicrobial resistance and infection control2025
Prevalence and antibiotic resistance profiles of ESKAPE pathogens in the neonatal intensive care unit of the women and newborn hospital in Lusaka, Zambia.
Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The burden and predictors of hospital-acquired infection in intensive care units across Sub-Sahara Africa: systematic review and metanalysis.BMC infectious diseases · 2025Pooled it
- Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages.Viruses · 2026Review
- Genomic analysis ofbioRxiv : the preprint server for biology · 2026Article
- Analysis of the Etiology and Antibiotic Resistance of Bacterial Infections in Newborns in a Chinese Tertiary Hospital: From 2019 to 2024.Infection and drug resistance · 2026Article
- Lytic bacteriophages targeting carbapenem-resistant Klebsiella pneumoniae isolated in a resource-limited Zambian laboratory.Access microbiology · 2026Article
- Antimicrobial resistance trends of ESKAPEE pathogens isolated from intensive care unit patients at a tertiary care hospital in Mogadishu, Somalia: a retrospective study (2020-2024).Frontiers in microbiology · 2026Article
- Article
- Development and internal validation of a nomogram for early prediction of hospital-acquired ESKAPE colonization or infection in very preterm infants using indicators available within 24 hours.Frontiers in pediatrics · 2026Article
- Impact of Multidisciplinary-Led Implementation of Antimicrobial Stewardship Programs in Zambia: Findings and Implications.Antibiotics (Basel, Switzerland) · 2025Article
- ScymicrosinFrontiers in microbiology · 2025Article
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5 authors.
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Abstract
backgroundBacterial contamination of the Neonatal Intensive Care Unit (NICU) poses a significant risk for cross-transmission, potentially leading to infections in vulnerable neonates. Key pathogens involved in NICU-acquired infections such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. are collectively known as ESKAPE pathogens. They are known for their antibiotic resistance, posing challenges for treatment. This study aimed to investigate the prevalence and antibiotic resistance profiles of ESKAPE pathogens in the NICU at the Women and Newborn Hospital (WNH).
methodsA total of 344 Samples were collected from different medical equipment, inanimate, animate surfaces and indoor air using standard microbiological methods. Antimicrobial susceptibility testing was then performed using the Kirby-Bauer method.
resultsBacterial contamination rate was 323/344 (93.9%), with 83/323 (25.7%) of samples containing ESKAPE pathogens. Antimicrobial susceptibility varied among ESKAPE pathogens with a total of 75/83 (90%) of the ESKAPE isolates being multi-drug resistant (MDR). Gram-negative isolates exhibited high resistance to β-lactams, carbapenems, and fluoroquinolones, with susceptibility to aminoglycosides, while Gram-positive isolates showed resistance to β-lactams and macrolides but remained largely susceptible to linezolid, clindamycin, and vancomycin.
conclusionThere was a high level of contamination with MDR ESKAPE pathogens in the NICU. This highlights the need for improved infection prevention and control measures as well as antimicrobial stewardship to prevent further resistance.
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