ArticleBMC gastroenterology2025
Doppler ultrasound and 2D shear wave ultrasound elastography for liver fibrosis evaluation in Fontan-associated liver disease.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Discordant 2D shear wave elastography values in post-Fontan patients with ascites: a potential interpretive pitfall.Journal of ultrasound · 2026Article
- Prognostic biomarkers in Fontan associated liver disease.Translational pediatrics · 2026Review
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Fontan operation improves survival in patients with single ventricle physiology but is associated with Fontan-associated liver disease (FALD), characterized by progressive fibrosis due to prolonged elevated central venous pressure. While 2D shear wave elastography (2D-SWE) can assess fibrosis, it often overestimates stiffness in congestive conditions. Doppler ultrasound, which evaluates hepatic hemodynamics, may complement 2D-SWE for fibrosis assessment. This study evaluated the diagnostic performance of Doppler ultrasound and 2D-SWE in assessing hepatic fibrosis in Fontan patients and compared the findings with biopsy-proven fibrosis severity.
methodA retrospective study was conducted on 27 Fontan patients who underwent Doppler ultrasound, 2D-SWE, and liver biopsy between January 2020 and December 2022. ROC curves and AUC values were used to assess diagnostic performance.
resultsAST to Platelet Ratio Index (APRI) and Fibrosis-4 index (FIB-4) scores demonstrated good discriminatory performance, with AUC values of 0.79 and 0.72, respectively. Resistive Index (RI) of hepatic artery showed moderate discriminatory performance (AUC = 0.62), while 2D-SWE demonstrated poor discriminatory ability (AUC = 0.35). When RI was combined with APRI, the AUC improved from 0.79 to 0.82.
conclusionAPRI and FIB-4 provided the most accurate assessment of significant fibrosis, while RI of hepatic artery may serve as a useful adjunct to serum biomarkers. Incorporating Doppler ultrasound into a multi-parametric model may improve fibrosis evaluation in Fontan patients.
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