ArticleBMC infectious diseases2025
The relationship between circadian syndrome and its components with Helicobacter pylori infection risk: a cross-sectional study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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8 authors.
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Abstract
backgroundCircadian syndrome (CircS) provides a more comprehensive reflection of metabolic health than metabolic syndrome (MetS), yet studies exploring its association with H.pylori infection are still limited. The study aimed to examine the association between CircS and its components, as well as H.pylori infection, among individuals undergoing routine health screenings.
methodsWe collected data from health examination population who underwent a ¹³C-urea breath test (¹³C-UBT) at a tertiary hospital in Northwest China from July 1, 2021, to June 30, 2023, for a cross-sectional study. The study population was divided into H. pylori-positive and H. pylori-negative groups based on H.pylori infection status, and a binary logistic regression model was constructed to analyze the relationship between H.pylori infection and CircS and its components.
resultsThe study included 29,621 individuals, after adjusting for covariates, H.pylori infection showed a significant association with the prevalence of CircS (OR 1.17, 95% CI 1.08,1.27, P < 0.001), with the association being modified by smoking. Additionally, some of the components of CircS were associated with an increased risk of H.pylori infection, including central obesity, lowered high-density lipoprotein-cholesterol (HDL-C), elevated blood pressure (BP), and short sleep (OR 1.12, 95% CI 1.06,1.19; OR 1.14,95% CI 1.08,1.20; OR 1.10,95% CI 1.04,1.17; OR 1.11, 95% CI 1.02,1.20). No significant association was found between depression, elevated fasting blood glucose (FBG) and elevated triglycerides (TG) and H.pylori infection.
conclusionsThis study identifies CircS as an independent risk factor for H.pylori infection, that smoking appears to modify this relationship, and that some of the CircS components are significantly and positively associated with H.pylori infection.
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