ArticleBMC microbiology2025
The role of gut microbes in drought adaptation in the five-toed jerboa (Orientallactaga sibirica).
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metabolic Adaptation and Pulmonary ceRNA Network Plasticity inInternational journal of molecular sciences · 2026Article
- Analysis of Gut Microbial Communities and Functions inMicroorganisms · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The composition of the gut microbiota of animals is closely linked to host health and environmental adaptability. It can increase the phenotypic plasticity of animals, thereby improving their ability to thrive in harsh environments. The five-toed jerboa (Orientallactaga sibirica) is widely distributed in various regions, particularly in western Inner Mongolia and Xinjiang, which are located in the arid western part of China, and is capable of tolerating an arid environment. However, the relationships between the five-toed jerboa’s adaptation to such conditions and its gut microbiota have not yet been studied. In this study, we aimed to investigate the relationships between the gut microbiota of the five-toed jerboa and their adaptations to drought and water scarcity. Five-toed jerboa individuals were subjected to two treatments: water deprivation (experimental group, EG) and normal drinking water intake (control group, CG). Fecal samples from both groups were collected for sequencing and analysis of the V3-V4 variable region using 16 S rRNA. The results indicated that while the microbial composition is similar, there are differences in the relative abundance of microbes. The dominant bacteria in both groups were Firmicutes and Bacteroidota. The relative abundances of various genera within the bacterial community were significantly altered, with the abundance of Lactobacillus being most affected. The alpha diversity of the gut microbiota significantly differed between the EG and CG on the 5th and 11th days of water stress, with the EG showing significantly greater diversity than the CG (ACE, Chao and Shannon index) (P < 0.05). PICRUSt prediction revealed that the abundance of metabolism-related genes remained relatively consistent in the CG; however, in the EG, the abundance of genes associated with metabolism and cellular processes increased as the duration of stress increased. The five-toed jerboa adapted to water stress conditions by increasing the abundances of short-chain fatty acid-producing bacterial genera and altering the diversity of its gut microbiota. The results of this study suggest that five-toed jerboa may adapt to arid and water-scarce environments by increasing the abundance of beneficial bacteria in their gut microbiota.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.