Evidence map›Paper›PMID 40764855›Full record

ArticleAnnals of surgical oncology2026

Comparison of Three Nebulizer Nozzles Used During Pressurized Intraperitoneal Aerosol Chemotherapy Procedures in a Rabbit Model with Peritoneal Surface Malignancies: NOMOS Project.

Abdelkader Taibi, Marie-Laure Perrin, Catherine Yardin, Julie Usseglio, Sylvaine Durand Fontanier, Sylvia M Bardet

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abdelkader TaibiCNRS, XLIM, UMR 7252, University Limoges, Limoges, France. abdelkader.taibi@chu-limoges.fr.ORCID http://orcid.org/0000-0002-1036-6474
Marie-Laure PerrinCNRS, XLIM, UMR 7252, University Limoges, Limoges, France.
Catherine YardinCNRS, XLIM, UMR 7252, University Limoges, Limoges, France.
Julie UsseglioCNRS, Institut de Recherche sur les Céramiques, UMR 7315, University Limoges, Limoges, France.
Sylvaine Durand FontanierCNRS, XLIM, UMR 7252, University Limoges, Limoges, France.
Sylvia M BardetCNRS, XLIM, UMR 7252, University Limoges, Limoges, France.

Funding

This work was also supported by funds from Groupement Interregional de Recherche Clinique et d'Innovation Sud-Ouest Outre-Mer Hospitalier (GIRCI SOHO, Appel à Projet APIK 2023) for NOMOS project and Ligue contre le cancer 87 for Pipalim and Gastronano projects. Experiments in microscopy were performed at the PLATINOM platform (www.unilim.fr\platinom). The PLATINOM platform benefits from the support of the Nouvelle Aquitaine region and the European Union (FEDER - PILIM project) as well as the This work was also supported by funds from Groupem
6 · The paper itself

Abstract

backgroundPressurized intraperitoneal aerosol chemotherapy (PIPAC) improves local drug delivery and has shown promising results for treating peritoneal surface malignancies (PSMs); however, comparative data on the performance of different PIPAC nozzles in disease-bearing models are limited.

objectiveThis study aimed to evaluate the therapeutic efficacy of three PIPAC nozzles in a rabbit model of PSM.

methodsNine immunocompetent New Zealand rabbits received intraperitoneal injections of VX2 tumor cells to induce PSM. The animals were randomized into three groups (n = 3) and treated with oxaliplatin-based PIPAC using CapnoPen

resultsCapnoPen

conclusionThis initial study suggests that the type of PIPAC nebulizer may influence therapeutic efficacy in a rabbit model with peritoneal metastasis, highlighting the need for further controlled studies to confirm these preliminary findings.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsDrug Delivery SystemsNebulizers and VaporizersPeritoneal NeoplasmsAerosolsAnimalsApoptosisDisease Models, AnimalOxaliplatinRabbitsAerosolsOxaliplatinAnimal modelIntraperitoneal chemotherapyNebulization nozzleOncological responsePeritoneal metastasesPIPAC

Identifiers

PMID40764855
PMCPMC12901196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.