ReviewInternational urology and nephrology2026
A macrophage-endothelial cell axis in kidney diseases.
Review in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundKidney diseases, including both acute and chronic conditions, present significant global health challenges. Macrophages and endothelial cells play critical roles in the onset and progression of these diseases. This review aims to explore the bidirectional interactions between macrophages and endothelial cells and their roles in kidney diseases.
methodBy analyzing existing literature, this paper focuses on discussing the interaction mechanisms between macrophages and endothelial cells in acute kidney injury (AKI) and chronic kidney disease (CKD), including cytokine secretion, exosome transport, and adhesion molecule expression.
resultResearch demonstrates that macrophages regulate endothelial function and angiogenesis through cytokine release, exosome transfer, and adhesion molecules, while endothelial cells control macrophage recruitment and activation via adhesion molecules. These interactions are essential in balancing kidney injury and repair, as well as modulating inflammation and fibrosis.
conclusionThe current research is mostly based on the animal models and has not fully addressed the issue of species-specific differences. Future research should combine multi-omics technology and patient-derived organoids to validate therapeutic targets and promote clinical translational research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.