Evidence map›Paper›PMID 40764839›Full record

Trial reportEuropean journal of applied physiology2026

Physiological responses to matched ramp-incremental exercise on recumbent cycle ergometer and treadmill in patients with heart failure.

Rebeca Nunes Silva, Janos Porszasz, Carrie Ferguson, Patrícia Rehder-Santos, Meliza Goi Roscani, Claudio Ricardo de Oliveira, Aparecida Maria Catai, William W Stringer, Audrey Borghi-Silva

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rebeca Nunes SilvaDepartment of Physiotherapy, Cardiopulmonary Physiotherapy Laboratory (LACAP), Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-7273-2399
Janos PorszaszDivision of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Carrie FergusonDivision of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Patrícia Rehder-SantosDepartment of Physiotherapy, Cardiovascular Physiotherapy Laboratory (LFCV), Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
Meliza Goi RoscaniDepartment of Medicine, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
Claudio Ricardo de OliveiraDepartment of Medicine, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
Aparecida Maria CataiDepartment of Physiotherapy, Cardiovascular Physiotherapy Laboratory (LFCV), Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil.
William W StringerDivision of Respiratory and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Audrey Borghi-SilvaDepartment of Physiotherapy, Cardiopulmonary Physiotherapy Laboratory (LACAP), Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil. audrey@ufscar.br.ORCID http://orcid.org/0000-0002-3891-6941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise intolerance is a cardinal symptom in patients with heart failure (HF), and cardiopulmonary exercise testing (CPET) is the gold standard method for its assessment. The treadmill and cycle ergometers (upright and recumbent) are used in clinical practice for tracking disease progression and risk stratification, therefore, understanding the physiological differences related to ergometer is important. The aim of this study was to compare the physiological responses to exercise on treadmill and recumbent cycle ergometer in patients with HF with reduced ejection fraction (HFrEF) using a linear ramp protocol matched with controlled work rate (WR) profiles. Thirteen patients with HFrEF (left ventricular ejection fraction: 34.5% [28.7-47%]) were included. They performed two randomized ramp-incremental CPETs, on recumbent cycle and treadmill, both with incrementation rates of 10 watts per minute (W/min). The cardiorespiratory data obtained in both tests were WR-aligned and iso-WR responses were compared. Patients reached similar WR peak on both exercise modalities (84 ± 23 vs 91 ± 26 watts, P = 0.133, for recumbent cycle and treadmill, respectively) with no differences in ventilatory efficiency (

Indexed as

ExerciseExercise TestExercise ToleranceHeart FailureAgedFemaleHumansMaleMiddle AgedOxygen ConsumptionStroke VolumeCardiopulmonary exercise testingExercise protocolHFrEFRecumbent ergometerRisk stratificationTreadmill

Identifiers

PMID40764839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.