Exploring the nucleus accumbens circuit and oxytocin therapy in a Sapap3 knockout mouse model of trichotillomania.

Yuan Wang, Jingjing Yu, Rui Ma, Yundong Chen, Shihao Lu, Jianqun Fang

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yuan Wang *Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.

Jingjing Yu *Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.

Rui MaSchool of First Clinical, Ningxia Medical University, No.1106 South Shengli Street, Yinchuan, 750004, Ningxia, China.

Yundong ChenSchool of First Clinical, Ningxia Medical University, No.1106 South Shengli Street, Yinchuan, 750004, Ningxia, China.

Shihao LuSchool of First Clinical, Ningxia Medical University, No.1106 South Shengli Street, Yinchuan, 750004, Ningxia, China.

Jianqun FangInstitute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. fjq7887215@163.com.

Funding

National Natural Science Foundation of China 82460277Ningxia Medical University's scientific research project XT2024031

6 · The paper itself

Abstract

Trichotillomania (TTM), an understudied psychiatric disorder, was investigated using Sapap3 knockout (KO) mice to elucidate nucleus accumbens (NAc) circuit dysfunction and oxytocin's therapeutic potential. Under aversive conditions, KO mice exhibited TTM-like behavioral phenotypes compared to wild-type (WT) controls: elevated anxiety-like behavior (reduced total distance 33328.45 ± 6703.97 mm vs. WT 47787.22 ± 12221.33 mm; decreased standing episodes 34.20 ± 19.41 vs. WT 58.10 ± 15.55; increased immobility duration 175.05 ± 54.46 s vs. WT 90.23 ± 70.22 s, all p < 0.05), excessive grooming duration (467.43 ± 94.98 s vs. WT 391.62 ± 86.44 s, p < 0.05), and impaired social interaction characterized by elevated aggression (70 ± 10% victory rate in tube-dominance test vs. WT, p < 0.05). Calcium imaging revealed NAc neuronal hypoactivity (peak ΔF/F

Indexed as

Nerve Tissue ProteinsNucleus AccumbensOxytocinTrichotillomaniaAnimalsBehavior, AnimalDisease Models, AnimalGroomingMaleMiceMice, KnockoutNerve Tissue ProteinsOxytocinSapap3 protein, mouseDopamine signaling pathwayNucleus accumbens (NAc)Oxytocin treatmentSapap3Trichotillomania (TTM)

Identifiers

PMID40764792

DOI10.1038/s41598-025-14076-y

PMCPMC12325644

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.