ArticleNature computational science2025
Virtual brain twins for stimulation in epilepsy.
Article in Nature computational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Digital Twins as the Implementation Layer of Precision Medicine in Pediatric Neurosurgery.Journal of Korean Neurosurgical Society · 2026Review
- Toward Optimizing Thalamic Deep Brain Stimulation for Cortical Modulation: A Surrogate Brain Approach.bioRxiv : the preprint server for biology · 2026Article
- Cerebrovascular Imaging-to-Graph Reconstruction for Individualized Digital Twin Brains.bioRxiv : the preprint server for biology · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Review
- Structural and Functional Connectivity Predict the Effects of Direct Brain Stimulation on Memory.bioRxiv : the preprint server for biology · 2026Article
- Alteration of functional connectivity and network properties after stereo-electroencephalography guided radiofrequency thermocoagulation.Chinese neurosurgical journal · 2026Article
- 3D printed pediatric head phantom for assessing deep epileptic sources localization.Computers in biology and medicine · 2026Article
- New directions for complex systems in contemporary neuroscience: a morphodynamic and emergent function approach.Frontiers in computational neuroscience · 2026Review
- Transcranial Temporal Interference Stimulation: A Brief Review of Architectures, Circuits, and Application Challenges.IEEE open journal of engineering in medicine and biology · 2026Article
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
- Virtual brain twins for stimulation in epilepsy.Nature computational science · 2025Article
- Arbor-TVB: a novel multi-scale co-simulation framework with a case study on neural-level seizure generation and whole-brain propagation.Frontiers in computational neuroscience · 2025Article
- Electroencephalography derived connectivity informing epilepsy surgical planning: Towards clinical applications and future perspectives.NeuroImage. Clinical · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Estimating the epileptogenic zone network (EZN) is an important part of the diagnosis of drug-resistant focal epilepsy and has a pivotal role in treatment and intervention. Virtual brain twins provide a modeling method for personalized diagnosis and treatment. They integrate patient-specific brain topography with structural connectivity from anatomical neuroimaging such as magnetic resonance imaging, and dynamic activity from functional recordings such as electroencephalography (EEG) and stereo-EEG (SEEG). Seizures show rich spatial and temporal features in functional recordings, which can be exploited to estimate the EZN. Stimulation-induced seizures can provide important and complementary information. Here we consider invasive SEEG stimulation and non-invasive temporal interference stimulation as a complementary approach. This paper offers a high-resolution virtual brain twin framework for EZN diagnosis based on stimulation-induced seizures. It provides an important methodological and conceptual basis to make the transition from invasive to non-invasive diagnosis and treatment of drug-resistant focal epilepsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.