Evidence map›Paper›PMID 40764748›Full record

ArticleThe European journal of neuroscience2025

The Glucocorticoid Receptor Co-Chaperone FKBP51 in the Adrenal Cortex Is Not Involved in Regulating Hypothalamic-Pituitary-Adrenal Activity in the Mouse.

London Aman, Vera Sterlemann, Veronika Kovarova, Sowmya Narayan, Margherita Springer, Daniela Harbich, Bianca Schmid, Benjamin Jurek, Mathias V Schmidt

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

London AmanResearch Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
Vera SterlemannResearch Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
Veronika KovarovaResearch Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
Sowmya NarayanResearch Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
Margherita SpringerResearch Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
Daniela HarbichResearch Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
Bianca SchmidMax Planck Institute of Psychiatry, Munich, Germany.
Benjamin JurekResearch Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.
Mathias V SchmidtResearch Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany.ORCID 0000-0002-3788-2268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The FK506 binding protein 51 (FKBP51) is a stress-modulating protein implicated in stress-related psychiatric disorders. While FKBP51 has been extensively studied in the brain and other tissues, its role in the adrenal gland, a key part of the stress response, remains unexplored. To investigate Fkbp5 gene expression and FKBP51 function in the adrenal gland, we examined expression in C57Bl/6 male and female mice and generated an adrenal cortex-specific Fkbp5 knockout (AS

Indexed as

Adrenal CortexHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemReceptors, GlucocorticoidTacrolimus Binding ProteinsAnimalsCorticosteroneFemaleMaleMiceMice, Inbred C57BLMice, KnockoutSocial DefeatStress, PsychologicalTacrolimus Binding Protein 5CorticosteroneReceptors, GlucocorticoidTacrolimus Binding Protein 5Tacrolimus Binding Proteinsadrenal cortexchronic social defeatFKBP5HPA axisstress response

Identifiers

PMID40764748
PMCPMC12325814

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.