Evidence map›Paper›PMID 40764744›Full record

ArticleCommunications biology2025

Epithelial characteristics of ovarian clear cell carcinoma at single-cell resolution.

Qinhao Guo, Xia Chen, Rui Bi, Haiming Li, Meng Liu, Xingzhu Ju, Zheng Feng, Jun Zhu, Yizhen Li, Xin Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Qinhao Guo *Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Xia Chen *Institute of Reproductive Medicine, Jiangsu Province Key Laboratory in University for Inflammation and Molecular Drug Target, School of Medicine, Nantong University, Nantong, China.
Rui Bi *Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Haiming Li *Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Meng Liu *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou, China.
Xingzhu JuDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Zheng FengDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Jun ZhuDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Yizhen LiDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Xin WangDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Qiuru HuangInstitute of Reproductive Medicine, Jiangsu Province Key Laboratory in University for Inflammation and Molecular Drug Target, School of Medicine, Nantong University, Nantong, China.
Jiaxin LiInstitute of Reproductive Medicine, Jiangsu Province Key Laboratory in University for Inflammation and Molecular Drug Target, School of Medicine, Nantong University, Nantong, China.
Xiaonan ZhouDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Ying ZhengDepartment of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou, China.
Bo ZhengState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou, China. bozheng@njmu.edu.cn.ORCID http://orcid.org/0000-0002-1496-0753
Xiaohua WuDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China. wu.xh@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2271-2514
Jun YuInstitute of Reproductive Medicine, Jiangsu Province Key Laboratory in University for Inflammation and Molecular Drug Target, School of Medicine, Nantong University, Nantong, China. yujun9117@126.com.ORCID http://orcid.org/0000-0003-3109-4102
Hao WenDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China. wenhao_fdc@163.com.ORCID http://orcid.org/0000-0002-9587-8742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian clear cell carcinoma (OCCC) represents a rare and aggressive subtype of epithelial ovarian cancer with distinctive clinical and molecular characteristics. However, the identification, origin, and molecular features of the malignant epithelial cells in OCCC remain poorly studied. We establish an OCCC-associated transcriptional landscape using single-cell RNA sequencing and investigated the properties of epithelial cells in tissues from normal ovaries, ovarian endometriosis, primary OCCC and recurrent OCCC to assess the status of malignant epithelial cells. We identify a specific subcluster of malignant epithelial cells and further analyze them to discover 173 candidate factors associated with OCCC. Regulon and pseudotime trajectory analyses reveal six transcription factors (TFs) and their corresponding targets among these candidate factors, highlighting their roles in OCCC onset and reoccurrence. Through experimental validation, we confirm the crucial involvement of STAT3, KLF5, and TRIM28 in the proliferation and migration of OVISE cells. Silencing these three TFs also results in the down-regulation of their associated TF targets linked to OCCC. Overall, we characterize complex malignant-like cell populations at single-cell resolution and highlighted several TFs and their targets, providing essential resources for understanding the regulatory mechanisms underlying OCCC initiation and recurrence.

Indexed as

Adenocarcinoma, Clear CellCarcinoma, Ovarian EpithelialEpithelial CellsOvarian NeoplasmsSingle-Cell AnalysisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansTranscription FactorsTranscription Factors

Identifiers

PMID40764744
PMCPMC12325770

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.