Evidence map›Paper›PMID 40764730›Full record

ArticleScientific reports2025

Interactive 3D segmentation for primary gross tumor volume in oropharyngeal cancer.

Mikko Saukkoriipi, Jaakko Sahlsten, Joel Jaskari, Lotta Orsmaa, Jari Kangas, Nastaran Rasouli, Roope Raisamo, Jussi Hirvonen, Helena Mehtonen, Jorma Järnstedt and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Interactive AI annotation of medical images in a virtual reality environment.International journal of computer assisted radiology and surgery · 2026
    Article
  3. Article
  4. Gradient Map-Assisted Head and Neck Tumor Segmentation: A Pre-RT to Mid-RT Approach in MRI-Guided Radiotherapy.Head and Neck Tumor Segmentation for MR-Guided Applications : First MICCAI Challenge, HNTS-MRG 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 17, 2024, proceedings · 2025
    Article
  5. Head and Neck Tumor Segmentation Using Pre-RT MRI Scans and Cascaded DualUNet.Head and Neck Tumor Segmentation for MR-Guided Applications : First MICCAI Challenge, HNTS-MRG 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 17, 2024, proceedings · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mikko SaukkoriipiDepartment of Computer Science, Aalto University School of Science, Espoo, Finland.
Jaakko SahlstenDepartment of Computer Science, Aalto University School of Science, Espoo, Finland.
Joel JaskariDepartment of Computer Science, Aalto University School of Science, Espoo, Finland.
Lotta OrsmaaFaculty of Information Technology and Communication Sciences, Computing Sciences, University of Tampere, Tampere, Finland.
Jari KangasFaculty of Information Technology and Communication Sciences, Computing Sciences, University of Tampere, Tampere, Finland.
Nastaran RasouliFaculty of Information Technology and Communication Sciences, Computing Sciences, University of Tampere, Tampere, Finland.
Roope RaisamoFaculty of Information Technology and Communication Sciences, Computing Sciences, University of Tampere, Tampere, Finland.
Jussi HirvonenDepartment of Radiology, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.
Helena MehtonenDepartment of Radiology, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.
Jorma JärnstedtDepartment of Radiology, Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.
Antti MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mohamed NaserDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Clifton FullerDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Benjamin KannArtificial Intelligence in Medicine Program, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Kimmo KaskiDepartment of Computer Science, Aalto University School of Science, Espoo, Finland. kimmo.kaski@aalto.fi.

Funding

Business Finland 10912/31/2022Research Council of Finland 345449
6 · The paper itself

Abstract

Radiotherapy is the main treatment modality of oropharyngeal cancer (OPC), in which an accurate segmentation of primary gross tumor volume (GTVt) is essential but also challenging due to significant interobserver variability and the time consumed in manual tumor delineation. For such a challenge an interactive deep learning (DL) based approach offers the advantage of automatic high-performance segmentation with the flexibility for user correction when necessary. In this study, we investigate an interactive DL for GTVt segmentation in OPC by introducing a novel two-stage Interactive Click Refinement (2S-ICR) framework and implementing state-of-the-art algorithms. Using the 2021 HEad and neCK TumOR dataset for development and an external dataset from The University of Texas MD Anderson Cancer Center for evaluation, the 2S-ICR framework achieves a Dice similarity coefficient of 0.722 ± 0.142 without user interaction and 0.858 ± 0.050 after ten interactions, thus outperforming existing methods in both cases.

Indexed as

Imaging, Three-DimensionalOropharyngeal NeoplasmsTumor BurdenAlgorithmsDeep LearningHumans

Identifiers

PMID40764730
PMCPMC12325674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.