ArticleScientific reports2025
Integrative metabolomics and system pharmacology reveal the antioxidant blueprint of Psoralea corylifolia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
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- In Silico Development of Novel Quinazoline-Based EGFR Inhibitors via 3D-QSAR, Docking, ADMET, and Molecular Dynamics.International journal of molecular sciences · 2026Article
- Structure-Based Virtual Screening and In Silico Evaluation of Marine Algae Metabolites as Potential α-Glucosidase Inhibitors for Antidiabetic Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2026Article
- In silico screening and molecular analyses identify apigenin from Scutellaria barbata as a potent AKT1 inhibitor in breast cancer.PloS one · 2026Article
- Integrated Network Toxicology and Metabolomics Reveal the Ovarian Toxicity Mechanisms of Chronic Carbofuran Exposure in Female Mice.International journal of molecular sciences · 2025Article
- α-Glucosidase Inhibition-Guided Network Pharmacology and Molecular Docking Reveal the Antidiabetic Potential ofInternational journal of molecular sciences · 2025Article
- Exploring the Therapeutic Potential of Epigallocatechin-3-gallate (Green Tea) in Periodontitis Using Network Pharmacology and Molecular Modeling Approach.International journal of molecular sciences · 2025Article
- Network pharmacology and experiments verify the effect of triptolide on extraocular muscle fibrosis.PloS one · 2025Article
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2 authors.
Funding
Abstract
Psoralea corylifolia is a well-known edible medicinal plant extensively used in traditional Chinese medicine. In this study, the methanolic extract of P. corylifolia was initially screened for its antioxidant capacity using multiple in vitro assays, including 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Antioxidant Power (FRAP), 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and Oxygen Radical Absorbance Capacity (ORAC) assays. Additionally, Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) values were calculated. To identify the key metabolites responsible for these effects, an LC-QTOF-MS/MS-based metabolite profiling approach was employed, resulting in the identification of 41 compounds. Among them, 18 compounds were selected based on drug-likeness and bioavailability scores, using multiple online databases. To explore their potential mechanisms of action, a network pharmacology approach was employed. A total of 83 of 86 genes overlapped with antioxidant-related disease genes, which were subsequently subjected to protein-protein interaction (PPI), gene ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The top-ranked genes were TDP1, APEX1, TOP2A, CTSD, and KLF5. Finally, the most promising compounds and their target genes were subjected to molecular docking and simulation studies to validate the antioxidant potential of P. corylifolia.
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