ArticleTrials2025
The efficacy and safety of intrawound vancomycin powder to prevent surgical site infection in adult scoliosis surgery (Vanco-SSIASS): study protocol for a prospective, randomized controlled, assessor‑blinded, open‑label, multicenter trial.
Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Unveiling the landscape of vancomycin in periprosthetic joint infections: a comprehensive bibliometric analysis.Annals of medicine and surgery (2012) · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundPostoperative surgical site infections (SSIs) following adult scoliosis deformity (ASD) correction surgery are receiving more attention globally. Intrawound vancomycin powder in spinal surgical wounds has emerged as a promising strategy to prevent SSIs in recent years. However, the efficacy and safety of intrawound vancomycin powder in preventing SSIs following ASD correction surgery are still very controversial. This protocol describes a prospective, randomized controlled, multicenter clinical trial aimed at verifying vancomycin's efficacy and safety.
methodsThis is a study protocol for multicenter randomized controlled trial on efficacy and safety of intrawound vancomycin powder in preventing SSIs after ASD correction surgery. Eligible ASD patients (n = 264) will be recruited from the orthopedic inpatients of three university-affiliated medical centers in China. They will be randomly assigned to receive either standard perioperative anti-SSIs treatment (control group, n = 132), or 1000 mg vancomycin for spray injection on the surgical site during the correction surgery with standard perioperative anti-SSIs treatment (intervention group, n = 132) using a block randomization method. DISCUSSION: Up to now, there is no RCT (randomized controlled trial) to investigate the efficacy and safety of intrawound vancomycin powder to prevent surgical site infection in adult scoliosis surgery. We believe the RCT introduced in the article will fill the gap in this field and guide the perioperative anti-infection clinical medication for adult spinal deformity correction surgery.
trial registrationChiCTR2200059883. Registered on May 13, 2022. https://www.chictr.org.cn/showproj.html?proj=166621.
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