ReviewStem cell research & therapy2025
Melatonin and angiogenesis potential in stem cells.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Melatonin accelerated angiogenesis activity of alginate-gelatin encapsulated endothelial progenitor cells in a mouse model of volumetric muscle loss.Journal of biological engineering · 2026Article
- Melatonin and the Dental Pulp: A Scoping Review.International endodontic journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Ischemic diseases, especially coronary artery diseases and myocardial infarction, are the leading cause of human death in the clinical setting. Unfortunately, most of the available clinical interventions can partially restore the function of ischemic myocardium, resulting in the progression of chronic heart failure.The induction of vascular tissue formation, hereafter known as angiogenesis, can provide blood perfusion and prevent the expansion of ischemia-related pathologies. In recent years, the discovery and advent of multiple stem cells into human regenerative medicine have led to the alleviation of certain end-stage pathological conditions via direct differentiation into the mature and functional cells or secretion of various cytokines and angiogenesis factors in a paracrine manner. Melatonin (mel) is a natural molecule with direct and indirect pleiotropic actions on different biological phenomena. This neurohormone is primarily known for its antioxidant, tumoricidal, and anti-inflammatory actions in several pathological conditions. Whether and how mel regulates the angiogenesis behavior of stem cells is currently under debate. Here, we collected and evaluated recent data related to the angiogenic properties of mel on stem cells. Data from the present article may help us in the development of new therapeutic regimes in patients with ischemic conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.