ArticleVirology journal2025
Multiple high-risk human papillomavirus infections exacerbate cervical lesion risk: epidemiological evidence from suining, Sichuan.
Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Repeated Detection of Vaccine-Preventable Anal HPV Genotypes in a Screened Cohort: A Retrospective Observational Study.Pathogens (Basel, Switzerland) · 2026Observational
- Informative HPV testing after conization and its impact on time-varying estimates: a GAMM-based cohort study.Frontiers in public health · 2026Article
- Initial different human papillomavirus infection statuses and subsequent infection risk: a decade-long longitudinal study.Journal of health, population, and nutrition · 2025Article
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10 authors.
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Abstract
backgroundStudies on the pathogenicity of single and multiple human papillomavirus (HPV) infections have reported inconsistent results. Moreover, no data on HPV epidemiology in the Suining region of China have been published.
methodsCervical samples were collected from women undergoing gynecological examinations at the Suining Central Hospital. Fluorescent polymerase chain reaction (PCR) was used for HPV genotyping, and cytological and pathological examinations were performed to analyze the correlation between the infection patterns of high-risk HPV types (single vs. multiple infections) and cervical lesions.
resultsThe most prevalent high-risk HPV types were HPV52, 58, 16, 53, and 51. The proportion of disease cases (cervical intraepithelial neoplasia or cervical cancer) in multiple infection groups (720/1,550) was significantly higher than that in single infection groups (2,109/6,498) (relative risk = 1.43, 95% confidence interval = 1.34-1.53, p < 0.001). A positive correlation was observed between the number of HPV infections and the proportion of disease cases (r = 0.839, p = 0.009).
conclusionMultiple HPV infections were significantly associated with more severe cervical lesions, and a higher infection multiplicity correlated with an increased pathogenic risk. Our findings support that multiple HPV infections significantly elevate cervical lesion risk, providing a basis for referring such patients to further examination.
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