Trial reportScientific reports2025
A randomized controlled trial of graded exercise rehabilitation enhances diaphragm function and exercise tolerance in patients with AECOPD.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Patient perspectives on harmonica playing as an intervention for chronic obstructive pulmonary disease: a qualitative study.BMJ open · 2026Trial
- Diaphragmatic Thickening Fraction and Excursion: Different Clinical Values in Non-Critically Ill Patients with AECOPD - An Exploratory Study.International journal of chronic obstructive pulmonary disease · 2026Observational
- The lung-muscle axis in COPD: a conceptual framework integrating evidence, mechanisms, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Body mass index-related heterogeneity in diaphragm thickening fraction response to exercise training in stable chronic obstructive pulmonary disease.Frontiers in physiology · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
To evaluate the improvement effect of graded exercise rehabilitation on diaphragm function, exercise function, and respiratory performance in AECOPD patients. 68 AECOPD patients admitted to the Respiratory and Critical Care Department of a tertiary hospital in Zunyi City. Patients were randomly divided into a study group and a control group (each group 34 patients), and then according to the grading criteria, patients in each group were divided into 3 levels, for a total of 6 groups. The control group used conventional rehabilitation, while the study group used graded exercise rehabilitation. Bedside ultrasound was used to monitor the changes in diaphragm function (DE, DTei, DTee, DTF), 6MWT, CAT score, mMRC questionnaire, non-invasive mechanical ventilation time, and hospital stay between two groups of patients before and after rehabilitation. Compared with before the rehabilitation intervention, the study group showed significant improvement in diaphragm movement compared to the control group (P < 0.05). The end-inspiratory, end-expiratory, and diaphragm thickening scores all improved compared to before, and the differences were statistically significant (P < 0.05); The 6MWT and CAT scores of the study group were significantly higher than those of the control group after the intervention, and the difference was statistically significant (P < 0.05); Compared with the control group, the study group had significantly less mechanical ventilation time and hospitalization time, and the difference was statistically significant (both P < 0.05); The total incidence of MV related complications in the study group was lower than that in the control group, and the difference was statistically significant (P < 0.05). There were no actual compression injuries, aspiration, deep vein thrombosis, atelectasis, etc. in either group; The mMRC questionnaire did not show statistical significance (P > 0.05), but there was improvement before the intervention. Graded exercise rehabilitation can effectively improve the overall diaphragm function of patients, and has a positive effect on enhancing exercise quality and endurance; Bedside ultrasound can dynamically and real-time observe the diaphragm movement status of AECOPD patients, objectively and directly evaluate the recovery of respiratory muscle function, and has important clinical value.
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