Evidence map›Paper›PMID 40764465›Full record

Observational studyCardiovascular and interventional radiology2025

Percutaneous Cryoneurolysis of Splanchnic Nerves for Pain Palliation in Patients with Pancreatic Cancer: A Single-Center Experience.

David-Dimitris Chlorogiannis, Ioannis Kotsantis, Panagiota Economopoulou, Anastasios Kyriazoglou, Stavros Spiliopoulos, Nikolaos Kelekis, Dimitris K Filippiadis

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David-Dimitris ChlorogiannisDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, Brigham and Women's Hospital, 75 Francis Str, Boston, MA, 02115, USA. dchlorogiannis@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-1596-9466
Ioannis KotsantisDepartment of Medical Oncology, 2nd Department of Internal Medicine, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 1 Rimini Str, 12462, Haidari/Athens, Greece.
Panagiota EconomopoulouDepartment of Medical Oncology, 2nd Department of Internal Medicine, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 1 Rimini Str, 12462, Haidari/Athens, Greece.
Anastasios KyriazoglouDepartment of Medical Oncology, 2nd Department of Internal Medicine, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 1 Rimini Str, 12462, Haidari/Athens, Greece.
Stavros Spiliopoulos2nd Department of Radiology, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 1 Rimini Str, 12462, Haidari/Athens, Greece.
Nikolaos Kelekis2nd Department of Radiology, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 1 Rimini Str, 12462, Haidari/Athens, Greece.
Dimitris K Filippiadis2nd Department of Radiology, Medical School, University General Hospital "ATTIKON", National and Kapodistrian University of Athens, 1 Rimini Str, 12462, Haidari/Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report safety and efficacy (on terms of long-term pain reduction results) after percutaneous splanchnic nerve cryoneurolysis for the treatment of refractory pancreatic cancer-related pain. MATERIALS AND

methodsThis single-center, institutional review board-approved, retrospective observational study recruited consecutive patients with pancreatic cancer-related pain refractory to conservative treatment who underwent CT-guided cryoneurolysis of the splanchnic nerves. Outcomes included overall pain reduction rate (> 4 pain score units in the VAS pain scores), technical success (successful cryoprobe placement at the level of interest), and opioid usage reduction.

resultsFifty patients were included (mean age 65 ± 7 years). Overall, clinically relevant pain reduction was achieved in 76% of the patients (38/50). Baseline mean self-reported pain score was 9.52 ± 0.6 (range 8-10) reduced to a mean value of 4.36 ± 2.9, 4.23 ± 3, and 4.43 ± 3.1 after 1, 6, and 12 months, respectively. Technical success was achieved in 100% (50/50) of the patients. Reduction in opioid analgesia usage was observed in 76% (38/50) of the patients. Median overall survival after treatment was 21 months (interquartile range: 6, 36). A statistically significant difference was observed in the self-reported pain scores at 1, 6, and 12 months in patients with and without infiltration of the celiac plexus. No grade > 1b complications, according to the modified CIRSE classification system, were reported.

conclusionThis retrospective study highlights that percutaneous cryoneurolysis of the splanchnic nerves is effective and offers long-lasting pain palliation in patients with refractory pancreatic cancer-related pain. This effect is more pronounced when the celiac plexus is not infiltrated by the tumor.

Indexed as

Cancer PainCryosurgeryPain ManagementPalliative CarePancreatic NeoplasmsSplanchnic NervesAgedFemaleHumansMaleMiddle AgedPain MeasurementRadiography, InterventionalRetrospective StudiesTomography, X-Ray ComputedTreatment OutcomeComputed tomographyCryoanalgesiaCryoneurolysisPainPancreatic cancerSplanchnic nerves

Identifiers

PMID40764465

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.