Evidence map›Paper›PMID 40764408›Full record

ArticleScientific reports2025

A smart pen prototype with adaptive algorithms for stabilizing handwriting tremor signals in Parkinson's disease.

Jéssica Cristina Tironi, Anita Fernandes, Renata Coelho Borges, Luis Augusto Silva, Wemerson Delcio Parreira

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jéssica Cristina TironiPolytechnic School, University of Vale do Itajaí (UNIVALI), Itajaí, 88302-901, SC, Brazil.
Anita FernandesPolytechnic School, University of Vale do Itajaí (UNIVALI), Itajaí, 88302-901, SC, Brazil.
Renata Coelho BorgesGraduate Program in Biomedical Engineering (PPGEB), Federal University of Technology - Paraná (UTFPR), Curitiba, 80230-901, PR, Brazil.
Luis Augusto SilvaDepartment of Computer Science, Faculty of Science, Universidad de Salamanca, Salamanca, 37008, Spain. luisaugustos@usal.es.
Wemerson Delcio ParreiraFaculty of Electrical Engineering, Polytechnic School, Pontifical Catholic University of Campinas (PUC-Campinas), Campinas, 13087-571, SP, Brazil. wemerson@puc-campinas.edu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents a smart pen prototype designed to dynamically mitigate hand tremors, thereby enhancing writing quality and user comfort for individuals with conditions such as Parkinson's disease. The device employs an accelerometer for real-time tremor detection, a microcontroller for rapid data processing, and a vibration motor to counteract tremor effects. Adaptive algorithms-including Fx-LMS, Fx-NLMS, a combined Fx-LMS/NLMS approach, RLS, and the Kalman Filter-were evaluated using signals from the NewHandPD dataset. Simulation results revealed that although the RLS algorithm achieved the lowest mean square error, the Kalman Filter converged approximately eight times faster, a finding that was confirmed through microcontroller tests and further validated on an orbital shaking table under constant and variable tremor conditions. These outcomes underscore the potential of the Kalman Filter as a non-invasive, adaptive solution for real-time tremor mitigation in assistive writing devices. Future improvements may include integrating additional sensors and further optimizing microcontroller performance to enhance overall adaptability and accuracy.

Indexed as

AlgorithmsHandwritingParkinson DiseaseTremorAccelerometryAdaptive AlgorithmsHumansAdaptive controlKalman FiltersParkinson’s diseasePen prototypeTremor mitigation

Identifiers

PMID40764408
PMCPMC12325923

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.