ReviewNature cell biology2025
The molecular basis of human transcription-coupled DNA repair.
Review in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Transcription remodeling and stalling by cisplatin-induced interstrand crosslinks.Nature chemical biology · 2026Article
- Oxidative stress triggers RNAPII arrest through PARylation and DNA damage.Nature communications · 2026Article
- Polymerase face-off: emerging concepts in transcription-replication coordination.EMBO reports · 2026Review
- PAF1C restores transcription after DNA damage independently of promoting histone mark deposition.EMBO reports · 2026Article
- Hierarchical mechanisms control the clearance of DNA lesion-stalled RNA polymerase II.Nature communications · 2026Article
- Review
- PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex.Nucleic acids research · 2025Article
- Expanding the landscape of nucleotide excision repair disorders: from discovery to therapy.The Journal of clinical investigation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The stalling of RNA polymerase II (RNAPII) on DNA lesions triggers transcription-coupled DNA repair (TCR). Although the initial assembly of the TCR complex is known, recent advances have substantially deepened our understanding of its mechanisms. The elongation factor ELOF1 and DNA-binding protein STK19 have been identified as key TCR factors, with new insights into their functions. Cryo-electron microscopy of repair intermediates and mutational analyses have elucidated how TCR proteins interact with damage-stalled RNAPII. A newly discovered transcription-coupled pathway resolves DNA-protein crosslinks using only early TCR proteins. Here we integrate these advances, outlining the TCR mechanism step by step. First we discuss how early TCR factors ubiquitylate RNAPII, then we examine the transition to later nucleotide excision repair stages, and finally, the fate of damage-stalled RNAPII. Despite these advancements, significant gaps remain in our understanding of TCR mechanisms and we discuss these along with potential future research directions.
Indexed as
Identifiers
40764391What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.