Evidence map›Paper›PMID 40764339›Full record

ArticleScientific reports2025

Gender differences in the association between adverse childhood experiences and early onset psoriasis.

Sarnai Arlud, Hang Xu, Yu Feng Bai, Narisu Bao, Altanhuyag Balnuud, Siriguleng Wuyun, Nabucha Xie, Narangerili Tong, Nagongbilige He, Wei Wen Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarnai ArludKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
Hang XuKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
Yu Feng BaiDepartment of Mongolian Psychosomatic Medicine, Inner Mongolia International Mongolian Hospital, Hohhot, Inner Mongolia, China.
Narisu BaoDepartment of Mongolian Psychosomatic Medicine, Inner Mongolia International Mongolian Hospital, Hohhot, Inner Mongolia, China.
Altanhuyag BalnuudDepartment of Mongolian Psychosomatic Medicine, Inner Mongolia International Mongolian Hospital, Hohhot, Inner Mongolia, China.
Siriguleng WuyunDepartment of Mongolian Psychosomatic Medicine, Inner Mongolia International Mongolian Hospital, Hohhot, Inner Mongolia, China.
Nabucha XieSchool of Mongolian Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Narangerili TongMongolian Medicine, Inner Mongolia Azitai Mongolian Medical Hospital, Ordos, Inner Mongolia, China.
Nagongbilige HeInstitute of Psychosomatic Medicine, Inner Mongolia Traditional Chinese & Mongolian Medical Research Institute, Hohhot, Inner Mongolia, China. nagongbilige@gjmyemail.gjmyy.cn.
Wei Wen WangKey Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, No. 16 Lincui Road, Chaoyang District, Beijing, 100101, China. wangww@psych.ac.cn.

Funding

Inner Mongolia Major Project 2017 NMGZDZX2017the National Natural Science Foundation of China 82071517, U21A20364, 31771217the Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences E2CX4115CX
6 · The paper itself

Abstract

Psoriasis, a chronic autoimmune skin disease, arises from both genetic predisposition and environmental factors, including Adverse Childhood Experiences (ACEs). This cross-sectional study investigated the association between ACEs, family history, and early-onset psoriasis (≤ 18 years), with particular attention to gender differences. Among 102 psoriasis patients (54 early-onset, 48 late-onset), the early-onset group demonstrated a higher proportion of females, greater prevalence of parental psoriasis, and elevated anxiety levels compared to the late-onset group. However, multivariable regression analysis revealed that parental psoriasis was not significantly associated with early-onset psoriasis. Exposure to three or more ACEs significantly associated with early-onset psoriasis (adjusted OR = 2.61, p = 0.014), with specific associations observed for emotional neglect, domestic violence, and loneliness. Gender-stratified analysis showed a stronger association in females (adjusted OR = 6.609, p = 0.016) than in males (adjusted OR = 2.494, p = 0.115), though no significant gender-ACEs interaction was detected (p = 0.289). These findings demonstrate a gender differences, dose-response relationship between ACEs and early-onset psoriasis, highlighting the potential value of early psychological interventions for at-risk individuals, particularly females with high ACE exposure.

Indexed as

Adverse Childhood ExperiencesPsoriasisAdolescentAdultAge of OnsetChildCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsSex FactorsYoung AdultAdverse childhood experiencesAge of psoriasis onsetFamily historyGenderPsoriasis vulgaris

Identifiers

PMID40764339
PMCPMC12325934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.