Evidence map›Paper›PMID 40764302›Full record

ArticleNature communications2025

CSLD5-mediated cell wall remodelling regulates tissue mechanics and shoot meristem growth.

Miao Lan, Yimin Zhu, Alexis Peaucelle, Xianmiao Zhu, Yangxuan Liu, Xuemin Cao, Aram Gurzadyan, Geshuang Gao, Wenjuan Cai, Jérémy Gruel and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The mechanical properties ofScience advances · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Miao Lan *Key Laboratory of Plant Carbon Capture, CAS Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China.ORCID http://orcid.org/0000-0002-1342-6321
Yimin Zhu *Key Laboratory of Plant Carbon Capture, CAS Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China.
Alexis Peaucelle *Institut Jean-Pierre Bourgin, INRAE, AgroParisTech, Université Paris-Saclay, 78000, Versailles, France.
Xianmiao Zhu *Key Laboratory of Plant Carbon Capture, CAS Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China.
Yangxuan LiuKey Laboratory of Plant Carbon Capture, CAS Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China.
Xuemin CaoKey Laboratory of Plant Carbon Capture, CAS Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China.
Aram GurzadyanSainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK.ORCID http://orcid.org/0000-0003-0618-9361
Geshuang GaoKey Laboratory of Plant Carbon Capture, CAS Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China.
Wenjuan CaiCore Facility Center, CAS Centre for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, China.
Jérémy GruelSainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK.
Kalina T HaasInstitut Jean-Pierre Bourgin, INRAE, AgroParisTech, Université Paris-Saclay, 78000, Versailles, France.ORCID http://orcid.org/0000-0002-3511-5719
Henrik JönssonSainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK.ORCID http://orcid.org/0000-0003-2340-588X
Olivier HamantLaboratoire de Reproduction et Développement des Plantes, Université de Lyon, ENS de Lyon, UCBL, INRAE, CNRS, 46 Allée d'Italie, 69364, Lyon, Cedex 07, France.ORCID http://orcid.org/0000-0001-6906-6620
Raymond WightmanSainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK.
Elliot MeyerowitzSainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK.ORCID http://orcid.org/0000-0003-4798-5153
Weibing YangKey Laboratory of Plant Carbon Capture, CAS Centre for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032, Shanghai, China. wbyang@cemps.ac.cn.ORCID http://orcid.org/0000-0002-2379-5729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New tissues and organs in plants develop from stem cells located in meristematic tissues. Cell wall-mediated mechanics has been proposed to play crucial roles in controlling stem cell activity. Here, we show that in Arabidopsis shoot apical meristems (SAMs) Cellulose Synthase Like-D5 (CSLD5)-mediated cell wall synthesis modulates tissue mechanics. The Myb-domain transcription factor MYB3R4 directly activates CSLD5 expression, leading to robust new cell wall synthesis in dividing cells. CSLD5 forms complexes with CESAs to guide cellulose-based wall construction. Disruption of CSLD5 results in reduced wall stiffness and altered expression of touch-responsive genes. Confining CSLD5 to L1 layer cells restores the mechanical properties and growth defects of csld5 SAMs, indicating molecular and cellular compensation across shoot meristem layers. We further demonstrate that epidermal expression of OsCSLD4 in rice enhances inflorescence meristem growth and seed production. Our results suggest a principle for breeding high yield crops through cell-type specific cell wall remodelling.

Indexed as

ArabidopsisArabidopsis ProteinsCell WallGlucosyltransferasesMeristemCelluloseGene Expression Regulation, PlantOryzaPlants, Genetically ModifiedPlant ShootsTranscription FactorsArabidopsis ProteinsAT2G27250 protein, ArabidopsisCellulosecellulose synthaseGlucosyltransferasesTranscription Factors

Identifiers

PMID40764302
PMCPMC12325914

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.